BMC Nephrology | |
Serum sclerostin is an independent predictor of mortality in hemodialysis patients | |
Rosa MA Moysés1  Vanda Jorgetti2  Rodrigo B Oliveira2  Fernando Godinho Zampieri3  Fabiana G Graciolli2  Luciene M dos Reis2  Rosilene M Elias2  Flávia Letícia Carvalho Gonçalves2  | |
[1] Universidade Nove de Julho (UNINOVE), Rua Iperoig, 690 ap 121 – Perdizes, São Paulo 05016-000, SP, Brazil;Nephrology Division, Universidade de São Paulo, São Paulo, Brazil;Emergency Medicine Division, Universidade de São Paulo, São Paulo, Brazil | |
关键词: Mortality risk; Hemodialysis; CKD-MBD; Chronic renal failure; Sclerostin; | |
Others : 1082546 DOI : 10.1186/1471-2369-15-190 |
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received in 2014-08-13, accepted in 2014-11-27, 发布年份 2014 | |
【 摘 要 】
Background
Sclerostin (Scl) has recently emerged as a novel marker of bone remodeling and vascular calcification. However, whether high circulating Scl is also a risk factor for death is not well established. The purpose of this study was to test whether serum Scl would be associated with mortality.
Methods
we measured serum Scl in a hemodialysis patients’ cohort, which was followed during a ten-year period. Competing risk regression models were applied, as during the follow-up, patients were exposed to both events kidney transplant and death.
Results
Ninety-one patients aged 42.3 ± 18.8 years (55% of male gender, 15% of diabetes) were included. During the follow-up, 32 patients underwent kidney transplant and 26 patients died. Non-survivals presented higher FGF23, higher Scl and lower creatinine. There was an association between all-cause mortality and higher Scl (HR = 2.2), higher age (HR = 1.04) and presence of diabetes (HR = 2.27), by competing risk analyses. Even including potential markers of mortality, as creatinine, FGF 23, and gender, Scl, age and diabetes remained significantly related to higher mortality.
Conclusion
Serum Scl is an independent predictor of mortality in dialysis patients. However, whether clinical interventions to modulate Scl would be able to improve these patients survival needs to be determined.
【 授权许可】
2014 Gonçalves et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20141224171503902.pdf | 209KB | download | |
Figure 1. | 34KB | Image | download |
【 图 表 】
Figure 1.
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