Lactate clearance cut off for early mortality prediction in adult sepsis and septic shock patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Sinto, R.^1 ; Widodo, D.^1 ; Pohan, H.T.^1

Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, CiptoMangunkusumo National Hospital, Jalan Diponegoro No 71, Jakarta, Indonesia^1

关键词: Cohort studies;    Confidence interval;    Mortality risk;    Proportional hazards;    Receiver operating characteristic analysis;    Sensitivity and specificity;    Septic shocks;    Small Sample Size;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012023/pdf
DOI  :  10.1088/1755-1315/125/1/012023

来源: IOP

【 摘 要 】

Previous lactate clearance cut off for early mortality prediction in sepsis and septic shock patient was determined by consensus from small sample size-study. We investigated the best lactate clearance cut off and its ability to predict early mortality in sepsis and septic shock patients. This cohort study was conducted in Intensive Care Unit of CiptoMangunkusumo Hospital in 2013. Patients' lactate clearance and eight other resuscitationendpoints were recorded, and theoutcome was observed during the first 120 hours. The clearance cut off was determined using receiver operating characteristic (ROC) analysis, and its ability was investigated with Cox's proportional hazard regression analysis using other resuscitation endpoints as confounders. Total of 268 subjects was included, of whom 70 (26.11%) subjects died within the first 120 hours. The area under ROC of lactate clearance to predict early mortality was 0.78 (95% % confidence interval [CI] 0.71-0.84) with best cut off was