Prevalence of measles antibodies among health care workers in Catalonia (Spain) in the elimination era

BMC Infectious Diseases

Angela Domínguez⁶  María Esteve³  José María Bayas²  Magda Campins⁵  Sonia Broner⁴  Josep Costa²  Eva Borràs⁴  Luis Urbiztondo¹ 

[1]Public Health Agency, Generalitat of Catalonia, Roc Boronat, 81-95, 08005 Barcelona, Spain

[2]Hospital Clínic, University of Barcelona, Barcelona, Spain

[3]Hospital Germans Trías, Autonomous University of Barcelona, Badalona, Barcelona, Spain

[4]CIBER Epidemiología y Salud pública (CIBERESP), Madrid, Spain

[5]Hospital Vall d’ Hebrón, Autonomous University of Barcelona, Barcelona, Spain

[6]Department of Public Health, University of Barcelona, Barcelona, Spain

关键词: MCV vaccination;    Health care workers;    Seroprevalence;    Measles;   

Others  :  1145936
DOI  :  10.1186/1471-2334-13-391

 received in 2012-11-05, accepted in 2013-08-21,  发布年份 2013

【 摘 要 】

Background

Interruption of measles transmission was achieved in Catalonia (Spain) in 2000. Six years later, a measles outbreak occurred between August 2006 and June 2007 with 381 cases, 11 of whom were health care workers (HCW).

The objective was to estimate susceptibility to measles in HCW and related demographic and occupational characteristics.

Methods

A measles seroprevalence study was carried out in 639 HCW from six public tertiary hospitals and five primary healthcare areas. Antibodies were tested using the Vircell Measles ELISA IgG Kit. Data were analyzed according to age, sex, type of HCW, type of centre and vaccination history.

The odds ratios (OR) and their 95% CI were calculated to determine the variables associated with antibody prevalence. OR were adjusted using logistic regression.

Positive predictive values (PPV) and the 95% confidence intervals (CI) of having two documented doses of a measles containing vaccine (MCV) for the presence of measles antibodies and of reporting a history of measles infection were calculated.

Results

The prevalence of measles antibodies in HCW was 98% (95% CI 96.6-98.9), and was lower in HCW born in 1981 or later, after the introduction of systematic paediatric vaccination (94.4%; 95% CI 86.4-98.5) and higher in HCW born between 1965 and 1980 (99.0%; 95% CI 97.0-99.8). Significant differences were found for HCW born in 1965–1980 with respect to those born in 1981 and after (adjusted OR of 5.67; 95% CI: 1.24-25.91).

A total of 187 HCW reported being vaccinated: the proportion of vaccinated HCW decreased with age. Of HCW who reported being vaccinated, vaccination was confirmed by the vaccination card in 49%. Vaccination with 2 doses was documented in only 50 HCW, of whom 48 had measles antibodies. 311 HCW reported a history of measles.

The PPV of having received two documented doses of MCV was 96% (95% CI 86.3-99.5) and the PPV of reporting a history of measles was 98.7% (95% CI 96.7-99.6).

Conclusions

Screening to detect HCW who lack presumptive evidence of immunity and vaccination with two doses of vaccine should be reinforced, especially in young workers, to minimize the risk of contracting measles and infecting the susceptible patients they care for.

【 授权许可】

   
2013 Urbiztondo et al.; licensee BioMed Central Ltd.

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