BMC Medicine | |
Models of disease behavior in idiopathic pulmonary fibrosis | |
Harold R. Collard2  Brett Ley2  Kerri A. Johannson1  | |
[1] Department of Medicine, University of Calgary, 6th Floor - 4448 Front Street S.E., Calgary T3M-1M4, AB, Canada;Department of Medicine, University of California, San Francisco, Box 0111, 505 Parnassus Avenue, San Francisco 94143, CA, USA | |
关键词: Prognosis; Interstitial lung disease; Idiopathic pulmonary fibrosis; Biological markers; | |
Others : 1227207 DOI : 10.1186/s12916-015-0403-7 |
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received in 2015-04-15, accepted in 2015-06-19, 发布年份 2015 | |
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【 摘 要 】
Idiopathic pulmonary fibrosis is a diffuse parenchymal lung disease of unknown cause. The natural history of disease can vary considerably, making it difficult to predict the clinical trajectory for an individual patient. Accurate prognostication is desirable for clinical management as well as for cohort enrichment in clinical trials of therapeutics. Clinical and biomarker models of disease behavior have been developed to improve prognostication in idiopathic pulmonary fibrosis, with moderate predictive capabilities. Integrated prediction models that combine both clinical and biomarker variables will improve prognostication for patients and improved cohort enrichment strategies for clinical trials. This goal may be best achieved through collaborative patient registries with prospectively collected biological samples that allow for characterization of disease behavior in idiopathic pulmonary fibrosis.
【 授权许可】
2015 Johannson et al.
【 预 览 】
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