Analyzing pathways from childhood maltreatment to internalizing symptoms and disorders in children and adolescents (AMIS): a study protocol

BMC Psychiatry

Kai von Klitzing⁵  Marcus Ising⁶  Sandra Scheuer⁶  Christiane Wolf⁶  Eva Neudecker¹  Elena Giourges¹  Anna Costa¹  Martin J. Binser¹  Leonhard Resch⁵  Anna Andreas⁵  Jan Keil⁵  Jenny Horlich²  Tobias Stalder³  Andrea Michel⁵  Susan Sierau⁵  Katrin Hoffmann²  Bertram Müller-Myhsok⁴  Manfred Uhr⁶  Maria Kurz-Adam¹  Clemens Kirschbaum³  Annette M. Klein⁵  Lars O. White⁵ 

[1] Stadtjugendamt München (Child Protection Services Munich), Munich, Germany;Amt für Jugend, Familie und Bildung Leipzig (Child Protection Services Leipzig), Leipzig, Germany;Department of Psychology, Technical University of Dresden, Dresden, Germany;University of Liverpool, Institute of Translational Medicine, Liverpool L69 3BX, UK;Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany;Max Planck Institute of Psychiatry, Munich, 80804, Germany

关键词: Cognitive-emotional strategies;    Gene-environment interaction;    HPA axis;    Neuroendocrine functioning;    Developmental pathways;    Internalizing disorders;    Developmental psychopathology;    Maltreatment;   

Others  :  1217021
DOI  :  10.1186/s12888-015-0512-z

 received in 2014-12-02, accepted in 2015-05-29,  发布年份 2015

【 摘 要 】

Background

Effective interventions for maltreated children are impeded by gaps in our knowledge of the etiopathogenic mechanisms leading from maltreatment to mental disorders. Although some studies have already identified individual risk factors, there is a lack of large-scale multilevel research on how psychosocial, neurobiological, and genetic factors act in concert to modulate risk of internalizing psychopathology in childhood following maltreatment. To help close this gap, we aim to delineate gender-specific pathways from maltreatment to psychological disorder/resilience. To this end, we examine the interplay of specific maltreatment characteristics and psychological, endocrine, metabolomic, and (epi-)genomic stress response patterns as well as cognitive-emotional/social processes as determinants of developmental outcome. Specifically, we will explore endocrine, metabolomic, and epigenetic mechanisms leading from maltreatment to a higher risk of depression and anxiety disorders.

Methods/design

Four large samples amounting to a total of N = 920 children aged 4–16 years will be assessed: Two cohorts with prior internalizing psychopathology and controls will be checked for maltreatment and two cohorts with substantiated maltreatment will be checked for internalizing (and externalizing) psychopathology. We will apply a multi-source (interview, questionnaires, official records), multi-informant strategy (parents, children, teachers) to assess maltreatment characteristics (e.g., subtypes, developmental timing, chronicity) and psychopathological symptoms, supplemented with multiple measurements of risk and protective factors and cutting-edge laboratory analyses of endocrine, steroid metabolomic and epigenetic factors. As previous assessments in the two largest samples are already available, longitudinal data will be generated within the three year study period.

Discussion

Our results will lay the empirical foundation for (a) detection of early biopsychosocial markers, (b) development of screening measures, and (c) multisystem-oriented interventions in the wake of maltreatment.

【 授权许可】

   
2015 White et al.

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