Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children

BMC Infectious Diseases

Cinzia Marano⁵  Jean-Yves Pirçon⁵  Volker Vetter⁵  Werner Kroeniger⁵  Thomas Harder¹  Rolf-Werner Blasius⁶  Jan-Christof Bohn⁴  Susanne Wiedemann²  Gerhard Grevers³ 

[1] Skandinaviendamm 251, 24109, Kiel, Germany;Am Plärrer 25, Nürnberg, Germany;ENT Center, Prinzenweg 1, 82319, Starnberg, Germany;ENT Center, Markt 18, 09648, Mittweida, Germany;GlaxoSmithKline Vaccines, Wavre, Belgium;ENT Center, Kaiserstrasse 8, 33790, Halle, Germany

关键词: Antibiotic resistance;    Tympanocentesis;    Haemophilus influenzae;    Streptococcus pneumoniae;    otitis media;   

Others  :  1175140
DOI  :  10.1186/1471-2334-12-312

 received in 2012-03-06, accepted in 2012-10-25,  发布年份 2012

【 摘 要 】

Background

Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized.

Methods

In a prospective non-interventional study in German children between 3 months and less than 60 months of age with Ear, Nose and Throat Specialist –confirmed AOM, middle ear fluid was obtained by tympanocentesis (when clinically indicated) or by careful sampling of otorrhea through/at an existing perforation.

Results

In 100 children with severe AOM, Haemophilus influenzae was identified in 21% (18/21, 85.7% were non-typeable [NTHi]), Streptococcus pneumoniae in 10%, S. pyogenes in 13% and Moraxella catarrhalis in 1%. H. influenzae was the most frequently identified pathogen in children from 12 months of age. H. influenzae and S. pneumoniae were equally prevalent in children aged 3–11 months, but S. pyogenes was most frequently isolated in this age group. NTHi AOM disease appeared prevalent in all ages.

Conclusions

NTHi, S. pneumoniae and S. pyogenes are implicated as important causes of complicated AOM in children in Germany. NTHi disease appears prevalent in all ages. The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating.

【 授权许可】

   
2012 Grevers et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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