Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria

BMC Clinical Pharmacology

Rathankar Rao²  Waheeta Hopper¹  Prabakaran Pitchandi¹ 

[1] Department of Bioinformatics, School of Bioengineering, Faculty of Engineering and Technology, SRM University, Kattankulathur, 603203, Tamil, Nadu, India;Sr. Application Scientist, Apsara Innovations, #218/1, 2nd floor, Kammanahalli main road, 3rd block, Kalyana nagar, Bangalore 560 043, India

关键词: IC50;    Drug design;    Pathogenic bacteria;    Chorismate synthase;    Shikimate pathway;    Biological database;   

Others  :  860588
DOI  :  10.1186/2050-6511-14-29

 received in 2012-08-27, accepted in 2013-04-24,  发布年份 2013

【 摘 要 】

Background

Infectious diseases are major public health problem. It is increasingly affecting more than 50 million people worldwide. Targeting shikimate pathway could be efficiently used for the development of broad spectrum antimicrobial compound against variety of infectious diseases. Chorismate synthase is an enzyme in shikimate pathway that catalyzes Phosphoenol pyruvate to chorismate in most of the prokaryotic bacteria. This step is crucial for its growth, since Chorismate acts as a precursor molecule for the synthesis of aromatic amino acids. Hence, we present a comprehensive database of Chorismate Synthase Database (CSDB) which is a manually curated database. It provides information on the sequence, structure and biological activity of chorismate synthase from shikimate pathway of pathogenic bacteria. Design of suitable inhibitors for this enzyme, hence could be a probable solution to destroy its proteomic machinery and thereby inhibit the bacterial growth.

Description

The aim of this study was to characterise chorismate synthase enzyme belonging to pathogenic bacteria to analysis the functional and structural characterization of chorismate synthase is very important for both structure-based and ligand based drug design.

Conclusions

The broad range of data easy to use user interface makes csdb.in a useful database for researchers in designing drugs.

【 授权许可】

   
2013 Pitchandi et al.; licensee BioMed Central Ltd.

【 图 表 】

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