Total parathyroidectomy with trace amounts of parathyroid tissue autotransplantation as the treatment of choice for secondary hyperparathyroidism: a single-center experience

BMC Surgery

Lei Cao¹  Zhen Lv¹  Yanming Ge²  Yanning Li¹  Songjian Duan¹  Jian Zhu¹  Peng Zhou¹  Ziyi Fan¹  Luming Zheng¹  Dayong Zhuang¹  Qingqing He¹ 

[1] Department of Thyroid and Breast Surgery, Jinan Military General Hospital of PLA, No.25 Shifan Road, Jinan 250031, People's Republic of China;Blood Purification Center, Jinan Military General Hospital of PLA, Jinan 250031, People's Republic of China

关键词: Autotransplantation;    Parathyroid hormone;    Total parathyroidectomy;    Chronic renal failure;    Secondary hyperparathyroidism;   

Others  :  866846
DOI  :  10.1186/1471-2482-14-26

 received in 2013-04-27, accepted in 2014-04-25,  发布年份 2014

【 摘 要 】

Background

The aim of the study was to evaluate total parathyroidectomy with trace amounts of parathyroid tissue (30 mg) as a surgical option in secondary hyperparathyroidism (sHPT) treatment.

Methods

From January 2008 to March 2012, 47 patients underwent parathyroidectomy. Comparisons of demographic data, symptoms, and preoperative or postoperative biochemistry were made between total parathyroidectomy with trace amounts of parathyroid tissue autotransplantation group and total parathyroidectomy group.

Results

Out of 47 cases, 45 had successful operation. 187 parathyroid glands identified at the initial operation were reported in 47 patients. 43 patients had been diagnosed with parathyroid hyperplasia, and 4 patients had a benign adenoma. After operation, pruritus, bone pain and muscle weakness disappeared, also serum PTH and serum phosphate were declined markedly as well. After discharge, two patients (in total parathyroidectomy group) were readmitted because of postoperative hypoparathyroidism. Graft-dependent recurrence was not observed in an average follow-up of 42 months.

Conclusions

Total parathyroidectomy with sternocleidomastoid muscle trace amounts of parathyroid tissue autotransplantation is considered to be a feasible, safe and effective surgical option for the patients with sHPT.

【 授权许可】

   
2014 He et al.; licensee BioMed Central Ltd.

【 图 表 】

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