A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial

BMC Public Health

Gregory A Hand³  Sara Wilcox³  Stephanie Burgess²  Xuemei Sui³  Steven N Blair⁴  Wesley Dudgeon⁵  Jason R Jaggers¹ 

[1] Arnold School of Public Health, PHRC, 921 Assembly St, Columbia, SC, 29208, USA;School of Nursing, University of South Carolina, Columbia, SC, USA;Department of Exercise Science, University of South Carolina, Columbia, SC, USA;Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA;Department of Health, Exercise and Sport Sciences, The Citadel, Charleston, SC, USA

关键词: Study design;    Self care;    Physical activity;    HIV;    Cardiovascular disease;    Randomized trial;   

Others  :  1162179
DOI  :  10.1186/1471-2458-13-502

 received in 2013-05-02, accepted in 2013-05-15,  发布年份 2013

【 摘 要 】

Background

While combination antiretroviral therapy has extended the life expectancy of those infected with human immunodeficiency virus (HIV), there is a high prevalence of comorbidities that increase the risk of cardiovascular morbidity and mortality among people living with HIV/AIDS (PLWHA). The side effects associated with antiretroviral therapy (ART) lead to multiple metabolic disorders, making the management of these metabolic issues and risk of cardiovascular disease (CVD) in those treated with ART a critical issue. Clinical research trials, primarily clinical exercise, rarely include this population due to unique challenges in research methods with underserved minority populations living with a life threatening illness like HIV/AIDS. This paper describes the rationale and design of a randomized clinical trial evaluating the feasibility of a home-based exercise program designed to increase physical activity (PA) and reduce the risk of CVD in PLWHA.

Methods/design

PLWHA being treated with ART will be randomly assigned to one of two groups: a home-based PA intervention or standard care. All participants will receive an educational weight loss workbook and pedometer for self-monitoring of PA. Only those in the intervention group will receive additional elastic Thera-bands® for strength training and behavioral telephone based coaching.

Discussion

This study will evaluate the feasibility of a home-based program designed to increase PA among PLWHA. Further, it will evaluate the effectiveness of such a program to decrease modifiable risk factors for CVD as a secondary outcome. This study was funded by the NIH/NINR R21 Grant 1R21NRO11281.

Trial registration

Clinical Trial Identifier NCT01377064

【 授权许可】

   
2013 Jaggers et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 1.

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