Metabolic syndrome, C-reactive protein and microalbuminuria in a rural Chinese population: a cross-sectional study

BMC Nephrology

Ningli Wang¹  Jiangping Wen³  Xiaohui Yang¹  Xinrong Duan¹  Fenghua Wang¹  Yuanbo Liang¹  Wen Huang²  Liping Jiang² 

[1] Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing, China;Department of Nephrology, Beijing TongRen Hospital, Capital Medical University, Beijing, China;Department of Laboratory Medicine, Beijing TongRen Hospital, Capital Medical University, Beijing, China

关键词: Epidemiology;    Inflammation;    Metabolic syndrome;    Microalbuminuria;   

Others  :  1082921
DOI  :  10.1186/1471-2369-14-118

 received in 2012-10-21, accepted in 2013-05-30,  发布年份 2013

【 摘 要 】

Background

Microalbuminuria is an early marker of chronic kidney disease (CKD). Previous studies have shown that either metabolic syndrome (MetS) or chronic inflammation is related to renal impairment. The aim of this study was to investigate the association between MetS, C-reactive protein (CRP) and microalbuminuria in a rural Chinese population.

Methods

This was a cross-sectional study using data from the Handan Eye Study. MetS was defined according to the Chinese Diabetes Society (CDS) criteria. CRP levels ≥ 3 mg/L were classified as high CRP. Microalbuminuria was defined as a urinary albumin/creatinine ratio (ACR) of 30–300 mg/g.

Results

We included 4191 subjects aged ≥ 30 years in this analysis. The prevalence of MetS and microalbuminuria in the group was 25.7% and 15.6%, respectively. The odds ratio (OR) of microalbuminuria in subjects with MetS was 1.25 (95% confidence interval (CI): 1.03 − 1.51) compared with those without microalbuminuria. In multivariate logistic regression analysis, high blood pressure (OR 1.36, 95% CI: 1.10 − 1.67) and high fasting blood glucose (OR 1.44, 95% CI: 1.17 − 1.76) were independently associated with microalbuminuria. Subjects with high CRP and MetS had a 1.46-fold greater risk of having microalbuminuria compared with those with low CRP without MetS (95% CI: 1.06 − 2.01).

Conclusions

In this rural Chinese population aged ≥30 years, MetS and microalbuminuria were independently related and the combination of high CRP and MetS was associated with an increased risk of microalbuminuria.

【 授权许可】

   
2013 Jiang et al.; licensee BioMed Central Ltd.

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