Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America

BMC Research Notes

Maurício Lima Barreto²  Lain C Pontes-de-Carvalho⁵  Philip John Cooper⁶  Laura Cunha Rodrigues³  Álvaro Augusto Cruz⁷  Jackson S da Conceição²  Rosimeire Leovigildo Fiaccone²  Camila A Figueiredo¹  Rafael Valente Veiga¹  Gabriela de S G Britto¹  Neuza Maria Alcântara-Neves⁴ 

[1] Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil;Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil;London School of Hygiene and Tropical Medicine, University of London, London, UK;Address: Instituto de Ciências da Saúde, Universidade Federal da Bahia, Avenida Reitor Miguel Calmon, sem n°, Canela, CEP – 40110-100 Salvador, Bahia, Brazil;Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil;Institute of Infection and Immunity, St George’s University of London, London, UK;ProAR – Nucleo de Excelência em Asma, Universidade Federal da Bahia, Salvador, Brazil

关键词: Treg cells;    Cytokines;    Asthma;    Atopy;    Total IgE;    Eosinophilia;    Helminth infections;   

Others  :  1123215
DOI  :  10.1186/1756-0500-7-817

 received in 2014-04-06, accepted in 2014-10-02,  发布年份 2014

【 摘 要 】

Background

Helminths are modulators of the host immune system, and infections with these parasites have been associated with protection against allergies and autoimmune diseases. The human host is often infected with multiple helminth parasites and most studies to date have investigated the effects of helminths in the context of infections with single parasite or types of parasites (e.g. geohelminths). In this study, we investigated how co-infections with three nematodes affect markers of allergic inflammation and asthma in children. We selected Ascaris lumbricoides and Trichuris trichiura, two parasites that inhabit the human intestine and Toxocara spp (Toxocara canis and/or T. cati), intestinal roundworms of dogs and cats that cause systemic larval infection in humans. These parasites were selected as the most prevalent helminth parasites in our study population.

Results

36.4% of children were infected with one parasite; 12.7% with 2 and 5.2% with 3. Eosinophilia >4% and >10% was present in 74.3% and 25.5% of the children, respectively. Total IgE > 200 IU/mL, sIgE ≥ 0.70 kU/L and SPT positivity were present in 59.7%, 37.1% and 30% of the children, respectively. 22.7% had recent asthma (12.0% non-atopic and 10.7% atopic). Helminth infections were associated in a dose-dependent way to decrease in the prevalence of SPT and increase in eosinophilia, total IgE, and the production of the regulatory cytokine IL-10 by unstimulated peripheral blood leukocytes. No association with asthma was observed.

Conclusions

Helminth co-infections in this population were associated with increased markers of the Th2 immune response, and with a host immune regulatory phenotype that may suppress allergic effector responses such as immediate hypersensitivity reactions in the skin.

【 授权许可】

   
2014 Alcântara-Neves et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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