Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas

BMC Cardiovascular Disorders

Gordon S Huggins¹  Kevin S Heffernan¹  Jeffrey T Kuvin¹  Eshan Patvardhan¹  Alyson Kelley-Hedgepeth¹  Erica L Brooks¹  Adeeb Al-Quthami¹  Patrick J Warner¹ 

[1]Division of Cardiology and Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA

关键词: Pulse wave velocity;    Augmentation index;    Arterial stiffness;    Bicuspid aortic valve;   

Others  :  857804
DOI  :  10.1186/1471-2261-13-19

 received in 2012-10-19, accepted in 2013-03-07,  发布年份 2013

【 摘 要 】

Background

We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness.

Methods

Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.

Results

There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).

Conclusions

Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta.

【 授权许可】

   
2013 Warner et al.; licensee BioMed Central Ltd.

【 图 表 】

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