Baseline of visceral fat area and decreased body weight correlate with improved pulmonary function after Roux-en-Y Gastric Bypass in Chinese obese patients with BMI 28–35 kg/m2 and Type 2 diabetes: a 6-month follow-up

BMC Endocrine Disorders

Weiping Jia²  Xiaodong Han¹  Jianzhong Di¹  Pin Zhang¹  Yuqian Bao²  Haoyong Yu²  Yinfang Tu² 

[1] Department of General surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai, China;Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Yishan Road 600, Shanghai, China

关键词: Pulmonary function test;    Type 2;    Diabetes;    Visceral fat;    Abdominal;    Obesity;    Body weight;   

Others  :  1215938
DOI  :  10.1186/s12902-015-0027-0

 received in 2014-12-29, accepted in 2015-06-01,  发布年份 2015

【 摘 要 】

Background

Associations between demographic data and pulmonary function have not been adequately examined in patients that underwent Roux-en-Y Gastric Bypass (RYGB). This study was designed to examine changes in body fat distribution and metabolic parameters after RYGB and whether these changes correlated with improved lung function.

Methods

A retrospective review of 32 ethnic Chinese with obesity with body mass index (BMI) 28–35 kg/m² and type 2 diabetes (T2DM) was conducted, focusing on metabolic outcomes and pulmonary function 6 months after RYGB.

Results

Forced expiratory volume during first second (FEV1), percentage of forced expiratory volume during first second (FEV1 [%pred]), forced vital capacity (FVC), and percentage of forced vital capacity (FVC [%pred]) all improved significantly after RYGB. These increases all were negatively correlated with decreases in body weight and visceral fat area (VFA). The improvements of FEV1, FEV1 [%pred] and FVC were also negatively correlated with baseline of body weight and VFA. Furthermore, increases in FEV1 and FVC were independently associated with baseline of VFA (β = −0.003, P = 0.000; β = −0.004, P = 0.002, respectively).

Conclusions

The baseline of VFA and weight loss induced by RYGB independently correlated with improved pulmonary function in Chinese patients.

【 授权许可】

   
2015 Tu et al.

【 图 表 】

Fig. 1.

Fig. 2.

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