Epicardial fat thickness is associated to type 2 diabetes mellitus in Korean men: a cross-sectional study

Cardiovascular Diabetology

Kyung Won Shim³  Hae Ran Park³  A Ri Byun³  Eunkyung Suh¹  Hyejin Chun² 

[1] Department of Family Medicine, Chaum Hospital, CHA University, 4-1, Cheongdam-dong, Gangnam-gu, Seoul 135-948, South Korea;Health Promotion Center, Ewha Womans University Mokdong hospital, Ewha Womans University School of Medicine, Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, South Korea;Departments of Family Medicine, Ewha Womans University Mokdong hospital, Ewha Womans University School of Medicine, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, South Korea

关键词: Visceral fat;    Low-dose chest CT;    Diabetes;    Epicardial fat tissue;   

Others  :  1208999
DOI  :  10.1186/s12933-015-0210-7

 received in 2015-02-05, accepted in 2015-04-15,  发布年份 2015

【 摘 要 】

Background

Visceral fat, including epicardial fat (EF) is recognized as a responsible factor of cardiovascular disease. The aim of this study was to investigate the relationship between EF and diabetes in Korean men.

Methods

EF thickness was measured in the left main coronary artery fat tissue (LMCA-fat) by low-dose chest CT scans in 1,048 Korean men (age above 20 years). LMCA-fat values were divided into quartiles and the prevalence of diabetes was analyzed based on the quartiles of LMCA-fat values using logistic regression.

Results

There were significant correlations between LMCA-fat and body mass index (r = 0.169, p = 0.004), waist circumference (r = 0.172, p < 0.001), fasting glucose (r = 0.106, p = 0.037) and HbA1c (r = 0.176, p < 0.001). The patients in the higher LMCA-fat quartiles were associated with higher prevalence of diabetes (p for trend <0.001). Even after adjustment for multiple covariates, this association still remained statistically significant (p for trend = 0.022). The highest LMCA-fat quartile group was significantly associated with diabetes compared to the lowest quartile group. (OR = 3.26, 95% CI = 1.17-9.12).

Conclusion

These findings indicate that increased EF thickness is independently associated with the prevalence of diabetes in Korean men.

【 授权许可】

   
2015 Chun et al.; licensee BioMed Central.

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