BMC Cancer | |
Incidence of breast and gynaecological cancers by ethnic group in England, 2001–2007: a descriptive study | |
Megan H Shirley2  Isobel Barnes2  Shameq Sayeed2  Alexander Finlayson2  Raghib Ali1  | |
[1] 17666 Al Ain, United Arab Emirates | |
[2] Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Oxford OX3 7LF, UK | |
关键词: Incidence; Ethnic groups; Epidemiology; Cervical cancer; Endometrial cancer; Ovarian cancer; Breast cancer; | |
Others : 1117847 DOI : 10.1186/1471-2407-14-979 |
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received in 2014-07-17, accepted in 2014-12-11, 发布年份 2014 | |
【 摘 要 】
Background
Although international comparisons reveal large geographical differences in the incidence of breast and gynaecological cancers, incidence data for ethnic groups in England remains scarce.
Methods
We compared the incidence of breast, ovarian, cervical and endometrial cancer in British Indians, Pakistanis, Bangladeshis, Black Africans, Black Caribbeans, Chinese and Whites between 2001 and 2007. We identified 357,476 cancer registrations from which incidence rates were calculated using mid-year population estimates from 2001 to 2007. Ethnicity was obtained through linkage to the Hospital Episodes Statistics database. Incidence rate ratios were calculated, comparing the 6 non-White ethnic groups to Whites, and were adjusted for age and income.
Results
We found evidence of differences in the incidence of all 4 cancers by ethnic group (p < 0.001). Relative to Whites, South Asians had much lower rates of breast, ovarian and cervical cancer (IRRs of 0.68, 0.66 and 0.33 respectively), Blacks had lower rates of breast, ovarian and cervical cancer but higher rates of endometrial cancer (IRRs of 0.85, 0.62, 0.72 and 1.16 respectively), and Chinese had lower rates of breast and cervical cancer (IRRs of 0.72 and 0.68 respectively). There were also substantial intra-ethnic differences, particularly among South Asians, with Bangladeshis experiencing the lowest rates of all 4 cancers.
Conclusions
Our study provides evidence that the risk of breast and gynaecological cancers varies by ethnic group and that those groups typically grouped together are not homogenous with regards to their cancer risk. Furthermore, several of our findings cannot be readily explained by known risk factors and therefore warrant further investigation.
【 授权许可】
2014 Shirley et al.; licensee BioMed Central Ltd.
【 预 览 】
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20150206010820497.pdf | 678KB | download | |
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Figure 1. | 42KB | Image | download |
【 图 表 】
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Figure 2.
【 参考文献 】
- [1]Office for National Statistics: Cancer Statistics Registrations, England (Series MB1), No. 41, 2010. London: Office for National Statistics; 2012. Available at: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/no--41--2010/index.html webcite
- [2]Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D: GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. IARC: Lyon; 2010. Available at: http://globocan.iarc.fr webcite
- [3]Parkin M, Khlat DM: Studies of cancer in migrants: rationale and methodology. Eur J Cancer 1996, 32(5):761-771. (Oxford, England: 1990)
- [4]Office for National Statistics: Ethnicity and National Identity in England and Wales 2011. London: Office for National Statistics; 2012. Available at: http://www.ons.gov.uk/ons/rel/census/2011-census/key-statistics-for-local-authorities-in-england-and-wales/rpt-ethnicity.html webcite
- [5]National Cancer Intelligence Network: Cancer Incidence and Survival by Major Ethnic Group, England, 2002–2006. London: National Cancer Intelligence Network; 2009.
- [6]Swerdlow AJ, Marmot MG, Grulich AE, Head J: Cancer mortality in Indian and British ethnic immigrants from the Indian subcontinent to England and Wales. Br J Cancer 1995, 72(5):1312-1319.
- [7]Jack RH, Davies EA, Moller H: Breast cancer incidence, stage, treatment and survival in ethnic groups in South East England. Br J Cancer 2009, 100(3):545-550.
- [8]Downing A, West RM, Gilthorpe MS, Lawrence G, Forman D: Using routinely collected health data to investigate the association between ethnicity and breast cancer incidence and survival: what is the impact of missing data and multiple ethnicities? Ethn Health 2011, 16(3):201-212.
- [9]Jack RH, Davies EA, Møller H: Breast cancer and age in Black and White women in South East England. Int J Cancer 2012, 130(5):1227-1229.
- [10]Grulich AE, Swerdlow AJ, Head J, Marmot MG: Cancer mortality in African and Caribbean migrants to England and Wales. Br J Cancer 1992, 66(5):905-911.
- [11]Jack RH, Linklater KM, Hofman D, Fitzpatrick J, Møller H: Ethnicity coding in a regional cancer registry and in Hospital Episode Statistics. BMC Public Health 2006, 6:281. BioMed Central Full Text
- [12]Ali R, Barnes I, Cairns BJ, Finlayson AE, Bhala N, Mallath M, Beral V: Incidence of gastrointestinal cancers by ethnic group in England, 2001–2007. Gut 2012, 62:1692-1703.
- [13]Shirley MH, Sayeed S, Barnes I, Finlayson A, Ali R: Incidence of haematological malignancies by ethnic group in England, 2001–7. Br J Haematol 2013, 163(4):465-477.
- [14]World Health Organisation: International Statistical Classification of Diseases and Related Health Outcomes, 10th Revision. Geneva: World Health Organization; 1992.
- [15]Noble M, mcLennan D, Wilkinson K, Whitworth A, Barnes H, Dibben C: The English Indices of Deprivation 2007. London: Communities and Local Government; 2008.
- [16]Segi M: Cancer Mortality for Selected Sites in 24 Countries (1950–57). Sendai, Japan: Department of Public Health, Tohoku University of Medicine; 1960.
- [17]Easton DF, Peto J, Babiker AG: Floating absolute risk - an alternative to relative risk in survival and case–control analysis avoiding an arbitrary reference group. Stat Med 1991, 10:1025-1035.
- [18]Rubin DB: Multiple imputation for nonresponse in surveys. New York: Wiley; 1987.
- [19]Gathani T, Ali R, Balkwill A, Green J, Reeves G, Beral V, Moser KA: Ethnic differences in breast cancer incidence in England are due to differences in known risk factors for the disease: prospective study. Br J Cancer 2014, 110:224-229.
- [20]McCormack VA, Perry N, Vinnicombe SJ, Silva Idos S: Ethnic variations in mammographic density: a British multiethnic longitudinal study. Am J Epidemiol 2008, 168(4):412-421.
- [21]Sproston K, Mindell J: Health Survey for England. The health of minority ethnic groups. London: The Stationery Office; 2004:2006.
- [22]Coleman DA, Dubuc S: The fertility of ethnic minorities in the UK, 1960s-2006. Popul Stud 2010, 64(1):19-41.
- [23]McCormack VA, Mangtani P, Bhakta D, McMichael AJ, dos Santos SI: Heterogeneity of breast cancer risk within the South Asian female population in England: a population-based case–control study of first-generation migrants. Br J Cancer 2004, 90(1):160-166.
- [24]Kelly YJ, Watt RG, Nazroo JY: Racial/ethnic differences in breastfeeding initiation and continuation in the United Kingdom and comparison with findings in the United States. Pediatrics 2006, 118(5):e1428-1435.
- [25]Office for National Statistics: UK Census 2001. London: Office for National Statistics; Available at: http://www.ons.gov.uk/ons/guide-method/census/census-2001/index.html webcite
- [26]Anderson WF, Rosenberg PS, Menashe I, Mitani A, Pfeiffer RM: Age-related crossover in breast cancer incidence rates between black and white ethnic groups. J Natl Cancer Inst 2008, 100(24):1804-1814.
- [27]Clarke CA, Keegan TH, Yang J, Press DJ, Kurian AW, Patel AH, Lacey JV Jr: Age-specific incidence of breast cancer subtypes: understanding the black-white crossover. J Natl Cancer Inst 2012, 104(14):1094-1101.
- [28]Bhopal RS, Bansal N, Steiner M, Brewster DH: Does the 'Scottish effect' apply to all ethnic groups? All-cancer, lung, colorectal, breast and prostate cancer in the Scottish Health and Ethnicity Linkage Cohort Study. BMJ Open 2012, 2(5):e001957.
- [29]Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Ferlay J: Cancer Incidence in Five Continents, Volume X. IARC: Lyon; 2013. Available at: http://ci5.iarc.fr webcite
- [30]Goodman MT, Howe HL, Tung KH, Hotes J, Miller BA, Coughlin SS, Chen VW: Incidence of ovarian cancer by race and ethnicity in the United States, 1992–1997. Cancer 2003, 97(10 Suppl):2676-2685.
- [31]Jain RV, Mills PK, Parikh-Patel A: Cancer incidence in the south Asian population of California, 1988–2000. J Carcinog 2005, 4:21.
- [32]Saxena S, Copas AJ, Mercer C, Johnson AM, Fenton K, Erens B, Nanchahal K, Macdowall W, Wellings K: Ethnic variations in sexual activity and contraceptive use: national cross-sectional survey. Contraception 2006, 74(3):224-233.
- [33]Brekelmans CT: Risk factors and risk reduction of breast and ovarian cancer. Curr Opin Obstet Gynecol 2003, 15(1):63-68.
- [34]Barker RM, Baker MR: Incidence of cancer in Bradford Asians. J Epidemiol Community Health 1990, 44(2):125-129.
- [35]Fenton KA, Mercer CH, McManus S, Erens B, Wellings K, Macdowall W, Byron CL, Copas AJ, Nanchahal K, Field J, Johnson AM: Ethnic variations in sexual behaviour in Great Britain and risk of sexually transmitted infections: a probability survey. Lancet 2005, 365(9466):1246-1255.
- [36]Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 2008, 58(2):71-96.
- [37]Jemal A, Simard EP, Dorell C, Noone AM, Markowitz LE, Kohler B, Eheman C, Saraiya M, Bandi P, Saslow D, Cronin KA, Watson M, Schiffman M, Henley SJ, Schymura MJ, Anderson RN, Yankey D, Edwards BK: Annual Report to the Nation on the Status of Cancer, 1975–2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 2013, 105(3):175-201.
- [38]Sabates R, Feinstein L: The role of education in the uptake of preventative health care: the case of cervical screening in Britain. Soc Sci Med 2006, 62(12):2998-3010.
- [39]Ali R, Barnes I, Kan SW, Beral V: Cancer incidence in British Indians and British whites in Leicester, 2001–2006. Br J Cancer 2010, 103(1):143-148.
- [40]Sherman ME, Devesa SS: Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus. Cancer 2003, 98(1):176-186.
- [41]Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006, 295(13):1549-1555.
- [42]Jamison PM, Noone AM, Ries LA, Lee NC, Edwards BK: Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992 to 2008. Cancer Epidemiol Biomarkers Prev 2013, 22(2):233-241.
- [43]Reeves KW, Carter GC, Rodabough RJ, Lane D, McNeeley SG, Stefanick ML, Paskett ED: Obesity in relation to endometrial cancer risk and disease characteristics in the Women's Health Initiative. Gynecol Oncol 2011, 121(2):376-382.
- [44]Smith LK, Botha JL, Benghiat A, Steward WP: Latest trends in cancer incidence among UK South Asians in Leicester. Br J Cancer 2003, 89(1):70-73.
- [45]Gakidou E, Nordhagen S, Obermeyer Z: Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities. PLoS Med 2008, 5(6):e132.
- [46]Parkin DM, Nguyen-Dinh X, Day NE: The impact of screening on the incidence of cervical cancer in England and Wales. Br J Obstet Gynaecol 1985, 92(2):150-157.
- [47]Peto J, Gilham C, Fletcher O, Matthews FE: The cervical cancer epidemic that screening has prevented in the UK. Lancet 2004, 364(9430):249-256.
- [48]Pollock AM, Vickers N: Breast, lung and colorectal cancer incidence and survival in South Thames Region, 1987–1992: the effect of social deprivation. J Public Health Med 1997, 19(3):288-294.
- [49]Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR: Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 2009, 338:b2393.