Incidence of breast and gynaecological cancers by ethnic group in England, 2001–2007: a descriptive study

BMC Cancer

Megan H Shirley²  Isobel Barnes²  Shameq Sayeed²  Alexander Finlayson²  Raghib Ali¹ 

[1] 17666 Al Ain, United Arab Emirates

[2] Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Oxford OX3 7LF, UK

关键词: Incidence;    Ethnic groups;    Epidemiology;    Cervical cancer;    Endometrial cancer;    Ovarian cancer;    Breast cancer;   

Others  :  1117847
DOI  :  10.1186/1471-2407-14-979

 received in 2014-07-17, accepted in 2014-12-11,  发布年份 2014

【 摘 要 】

Background

Although international comparisons reveal large geographical differences in the incidence of breast and gynaecological cancers, incidence data for ethnic groups in England remains scarce.

Methods

We compared the incidence of breast, ovarian, cervical and endometrial cancer in British Indians, Pakistanis, Bangladeshis, Black Africans, Black Caribbeans, Chinese and Whites between 2001 and 2007. We identified 357,476 cancer registrations from which incidence rates were calculated using mid-year population estimates from 2001 to 2007. Ethnicity was obtained through linkage to the Hospital Episodes Statistics database. Incidence rate ratios were calculated, comparing the 6 non-White ethnic groups to Whites, and were adjusted for age and income.

Results

We found evidence of differences in the incidence of all 4 cancers by ethnic group (p < 0.001). Relative to Whites, South Asians had much lower rates of breast, ovarian and cervical cancer (IRRs of 0.68, 0.66 and 0.33 respectively), Blacks had lower rates of breast, ovarian and cervical cancer but higher rates of endometrial cancer (IRRs of 0.85, 0.62, 0.72 and 1.16 respectively), and Chinese had lower rates of breast and cervical cancer (IRRs of 0.72 and 0.68 respectively). There were also substantial intra-ethnic differences, particularly among South Asians, with Bangladeshis experiencing the lowest rates of all 4 cancers.

Conclusions

Our study provides evidence that the risk of breast and gynaecological cancers varies by ethnic group and that those groups typically grouped together are not homogenous with regards to their cancer risk. Furthermore, several of our findings cannot be readily explained by known risk factors and therefore warrant further investigation.

【 授权许可】

   
2014 Shirley et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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