Prevalence of hepatopathy in type 1 diabetic children

BMC Pediatrics

Mannan Khan³  Ahmed S Alenizi²  Musa D AlZahrani²  Nimer M Sulaiman²  Abdulrahman A Al-Hussaini¹ 

[1] Division of Pediatric Gastroenterology, Hepatology & Nutrition, University of King Saud bin Abdulaziz for Health sciences Children's Hospital, PO box 59046, King Fahad Medical City, Riyadh, 11525, Kingdom of Saudi Arabia;Division of pediatric Endocrinology Unit, Children Hospital, PO box 87341, King Saud, Medical City, Riyadh, 11642, Kingdom of Saudi Arabia;Department of Radiology, Children's hospital, PO box 7855, King Saud, Medical City, Riyadh, 11117, Kingdom of Saudi Arabia

关键词: Ultrasound;    Diabetes mellitus;    Type 1 diabetes;    Hepatic glycogenosis;    Hepatomegaly;    Fatty liver;   

Others  :  1170637
DOI  :  10.1186/1471-2431-12-160

 received in 2012-05-14, accepted in 2012-10-01,  发布年份 2012

【 摘 要 】

Background

The Prevalence of liver disease among diabetics has been estimated to be between 17% and 100%. Most of these data were obtained from adult studies. The aim of our study was to screen for liver disease among type 1 diabetic children.

Methods

Children with type 1 diabetes following in clinic have been examined for existence of liver disease, from November 2008 to November 2009. All were subjected to the following: History, physical examination, liver function tests, fasting lipid profile, HbA1C, and ultrasound of the liver. A hyperechogenic liver and/or hepatomegaly on ultrasound were attributed most likely to excess glycogen or fat in the liver, after negative extensive work-up to rule out other underlying liver disease.

Results

106 children with type 1 diabetes were studied: age ranged between 8 months to 15.5 years, sixty two patients were females. Twenty two patients (21%) were identified to have abnormal findings on ultrasound of the liver: 10 patients had hepatomegaly and 12 had hyperechogenic liver. The group with hyperechogenic liver had poorer glycemic control than patients with normal liver (Mean HbA1c 12.14% Vs 10.7%; P value = 0.09). Hyperechogenic liver resolved in 60% at 6 months follow-up upon achieving better glycemic control.

Conclusions

Hyperechogenic liver and/or hepatomegaly are not uncommon in children with type 1 diabetes and tend to be more prevalent among children with poor glycemic control. Type 1 diabetes related hepatopathy is reversible by optimizing glycemic control. Because of its safety, and reliability, ultrasound can be used to screen for hepatopathy in type 1 diabetic child.

【 授权许可】

   
2012 Al-Hussaini et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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