Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

Diabetology & Metabolic Syndrome

Carlos Terra¹  Marilia Brito Gomes²  Bianca Senger Vasconcelos Barros²  Fernanda Cruz Monteiro³ 

[1] Department of Gastroenterology, Pedro Ernesto Hospital, State University of Rio de Janeiro (UERJ), 20.551-030, Rio de Janeiro, RJ, Brazil;Department of Gastroenterology, Federal Hospital of Lagoa, 22470-050, Rio de Janeiro, RJ, Brazil;Department of Internal Medicine, Diabetes Unit, Pedro Ernesto Hospital, State University of Rio de Janeiro (UERJ), 20.551-030, Boulevard 28 de Setembro, 77 - 3º andar - Vila Isabel, CEP 20551-030, Rio de Janeiro, RJ, Brazil;Department of Radiology, Pedro Ernesto Hospital, State University of Rio de Janeiro (UERJ), 20.551-030, Rio de Janeiro, RJ, Brazil;

关键词: Type 1 diabetes;    Fatty liver;    NAFLD;    Steatosis;    Elastography;    Ultrasound;    Metabolic syndrome;   

DOI  :  10.1186/s13098-021-00649-0

来源: Springer

【 摘 要 】

BackgroundData on non-alcoholic fatty liver disease (NAFLD) in individuals with type 1 diabetes (T1D) is controversial and so far, there are no published data on the Brazilian population. We investigated the prevalence of steatosis and hepatic fibrosis in a population with T1D from a tertiary care center in Brazil and its associated factors.MethodsNinety-five participants with T1D, aged 39 ± 13 years, with disease duration of 21 ± 9 years, being 55 (57.9%) females, from a university hospital in Rio de Janeiro, were screened for NAFLD with hepatic ultrasound (US) and transient elastography (TE).ResultsPrevalence of steatosis was, respectively, 12.6% and 16.8% when US and TE were used for diagnosis of NAFLD. Fibrosis was present in 8.4% of participants. A total of 31.6% of participants had at least one of the hepatic exams altered, which was associated with higher body mass index, waist circumference, hip circumference and waist-to-hip ratio,, presence of metabolic syndrome and higher triglycerides levels, even within the normal range. After multivariate analysis, presence of steatosis was only associated with metabolic syndrome and its component, triglycerides.ConclusionIn our study, prevalence of NAFLD in ultrasound approximates the one found with TE. Fibrosis was not frequent. Screening should be reserved for participants with T1D and metabolic syndrome, as this was the main factor associated with NAFLD. Triglycerides levels were the only component of metabolic syndrome associated with steatosis. Further studies are necessary to determine the best screening strategy for NAFLD in individuals with T1D. Also, predisposing factors for development in fibrosis in T1D should be further explored in prospective studies.

【 授权许可】

CC BY