Surgical site infections following coronary artery bypass graft procedures: 10 years of surveillance data

BMC Infectious Diseases

David Paterson²  Christopher Coulter³  John Marquess¹  Prabha Lakhan¹  Mohana Rajmokan¹  Damin Si¹ 

[1]Centre for Healthcare Related Infection Surveillance and Prevention, Queensland Health, Brisbane, Australia

[2]University of Queensland Centre for Clinical Research, Brisbane, Australia

[3]The Prince Charles Hospital, Brisbane, Australia

关键词: Risk factors;    Pathogens;    Surgical site infections;    Coronary artery bypass graft surgery;   

Others  :  1127577
DOI  :  10.1186/1471-2334-14-318

 received in 2014-02-05, accepted in 2014-05-30,  发布年份 2014

【 摘 要 】

Background

Surgical site infections following coronary artery bypass graft (CABG) procedures pose substantial burden on patients and healthcare systems. This study aims to describe the incidence of surgical site infections and causative pathogens following CABG surgery over the period 2003–2012, and to identify risk factors for complex sternal site infections.

Methods

Routine computerised surveillance data were collected from three public hospitals in Queensland, Australia in which CABG surgery was performed between 2003 and 2012. Surgical site infection rates were calculated by types of infection (superficial/complex) and incision sites (sternal/harvest sites). Patient and procedural characteristics were evaluated as risk factors for complex sternal site infections using a logistic regression model.

Results

There were 1,702 surgical site infections (518 at sternal sites and 1,184 at harvest sites) following 14,546 CABG procedures performed. Among 732 pathogens isolated, Methicillin-sensitive Staphylococcus aureus accounted for 28.3% of the isolates, Pseudomonas aeruginosa 18.3%, methicillin-resistant Staphylococcus aureus 14.6%, and Enterobacter species 6.7%. Proportions of Gram-negative bacteria elevated from 37.8% in 2003 to 61.8% in 2009, followed by a reduction to 42.4% in 2012. Crude rates of complex sternal site infections increased over the reporting period, ranging from 0.7% in 2004 to 2.6% in 2011. Two factors associated with increased risk of complex sternal site infections were identified: patients with an ASA (American Society of Anaesthesiologists) score of 4 or 5 (reference score of 3, OR 1.83, 95% CI 1.36-2.47) and absence of documentation of antibiotic prophylaxis (OR 2.03, 95% CI 1.12-3.69).

Conclusions

Compared with previous studies, our data indicate the importance of Gram-negative organisms as causative agents for surgical site infections following CABG surgery. An increase in complex sternal site infection rates can be partially explained by the increasing proportion of patients with more severe underlying disease.

【 授权许可】

   
2014 Si et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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