期刊论文详细信息
BMC Infectious Diseases
Impaired distensibility of ascending aorta in patients with HIV infection
Theodore Kordossis3  Panayiotis D Ziakas3  Athanasios N Kontos3  Maria N Gamaletsou3  Sarah P Georgiadou3  Ioannis Moyssakis1  Nikolaos V Sipsas3  Alexandra Zormpala2 
[1] Cardiology Department, Laikon General Hospital of Athens, Mikras Asias 75, 11527, Athens, Greece;Radiology Department, Laikon General Hospital of Athens, Medical School, National and Kapodistrian University, Mikras Asias 75, 11527, Athens, Greece;Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital, Medical School, National and Kapodistrian University, Mikras Asias 75, 11527, Athens, Greece
关键词: Carotid artery intima-media thickness;    Atherosclerosis;    HAART;    Aortic distensibility;    HIV;   
Others  :  1175324
DOI  :  10.1186/1471-2334-12-167
 received in 2011-05-01, accepted in 2012-06-21,  发布年份 2012
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【 摘 要 】

Background

Our aim was to investigate the aortic distensibility (AD) of the ascending aorta and carotid artery intima-media thickness (c-IMT) in HIV-infected patients compared to healthy controls.

Methods

One hundred and five HIV-infected patients (86 males [82%], mean age 41 ± 0.92 years), and 124 age and sex matched HIV-1 uninfected controls (104 males [84%], mean age 39.2 ± 1.03 years) were evaluated by high-resolution ultrasonography to determine AD and c-IMT. For all patients and controls clinical and laboratory factors associated with atherosclerosis were recorded.

Results

HIV- infected patients had reduced AD compared to controls: 2.2 ± 0.01 vs. 2.62 ± 0.01 10-6 cm2 dyn-1, respectively (p < 0.001). No difference was found in c-IMT between the two groups. In multiadjusted analysis, HIV infection was independently associated with decreased distensibility (beta –0.45, p < 0.001). Analysis among HIV-infected patients showed that patients exposed to HAART had decreased AD compared to HAART-naïve patients [mean (SD): 2.18(0.02) vs. 2.28(0.03) 10-6 cm2 dyn-1, p = 0.01]. In multiadjusted analysis, increasing age and exposure to HAART were independently associated with decreased AD.

Conclusion

HIV infection is independently associated with decreased distensibility of the ascending aorta, a marker of subclinical atherosclerosis. Increasing age and duration of exposure to HAART are factors further contributing to decreased AD.

【 授权许可】

   
2012 Zormpala et al.; licensee BioMed Central Ltd.

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