Elevated plasma B-type natriuretic peptide concentration and resistive index, but not decreased aortic distensibility, associate with impaired blood flow at popliteal artery in type 2 diabetic patients

Endocrine Journal

Eiji Suzuki³  Jun Saito³  Yukio Horikawa¹  Yoshitaka Tajima³  Jun Takeda¹  Hiroshi Murase² 

[1] Department of Diabetes and Endocrinology, Gifu University School of Medicine, Gifu 501-1194, Japan;Department of Internal Medicine, Daiyukai General Hospital, Ichinomiya 491-8551, Japan;Department of Diabetes and Endocrinology, Gifu Prefectural General Medical Center, Gifu 500-8717, Japan

关键词: Lower extremity arterial disease;    B-type natriuretic peptide;    Aortic distensibility;    Peripheral vascular resistance;   

DOI  :  10.1507/endocrj.EJ14-0608

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(34)Blood flow in lower extremity arteries is frequently impaired in diabetic patients even though they have a normal ankle-brachial index (ABI 1.0-1.4).Risk factors contributing to this lower extremity arterial disease have not been fully elucidated.We enrolled 52 type 2 diabetic patients with normal ABI and 30 age-matched nondiabetic subjects consecutively admitted to our hospital.Plasma B-type natriuretic peptide (BNP) concentrations were measured.Distensibility in ascending thoracic and abdominal aortas as well as total flow volume and resistive index at popliteal artery were evaluated by gated magnetic resonance imaging.An automatic device was used to measure ABI and brachial-ankle pulse-wave velocity (baPWV).Diabetic patients showed lower distensibility in ascending thoracic aorta (p<0.001) and total flow volume (p<0.001) and higher baPWV (p<0.001) and resistive index (p=0.005) and similar BNP and distensibility in abdominal aorta compared to nondiabetic subjects.Simple linear regression analyses revealed that distensibility in ascending thoracic (p=0.019) and abdominal (p=0.030) aortas positively as well as baPWV (p=0.020), resistive index (p<0.001) and BNP (p<0.001) negatively correlated with total flow volume.Stepwise multiple regression analysis demonstrated that increased BNP and resistive index were independent risk factors for total flow volume in diabetic patients (r2=0.639, p<0.001).These results indicate that increased plasma BNP levels and peripheral vascular resistance, but not decreased aortic distensibility, associate with impaired blood flow in lower extremity arteries in diabetic patients.

【 授权许可】

Unknown