α-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides

BMC Complementary and Alternative Medicine

Sun Chul Kang¹  MinKyun Na²  Yong-Ha Park³  Vivek K Bajpai³ 

[1] Department of Biotechnology, Daegu University, Gyeongsan 712-714, Gyeongbuk, Korea;College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea;Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Gyeongbuk, Korea

关键词: Terpenoids;    Tyrosinase;    α-Glucosidase;    Taxoquinone;    Metasequoia glyptostroboides;   

Others  :  1178848
DOI  :  10.1186/s12906-015-0626-3

 received in 2014-10-01, accepted in 2015-03-18,  发布年份 2015

【 摘 要 】

Background

Nowadays plant derived natural compounds have gained huge amount of research attention especially in food and medicine industries due to their multitude of biological and therapeutic properties as alternative medicines.

Methods

In this study, a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides was evaluated for its α–glucosidase and tyrosinase inhibitory efficacy in terms of its potent anti-diabetic and depigmentation potential, respectively.

Results

As a result, taxoquinone at the concentration range of 100–3,000 μg/mL and 200–1,000 μg/mL showed potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively.

Conclusions

The findings of this study clearly evident potent therapeutic efficacy of an abietane diterpenoid taxoquinone isolated from M. glyptostroboides with a possibility for using it as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent.

【 授权许可】

   
2015 Bajpai et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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