α-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides

BMC Complementary and Alternative Medicine

Research Article

MinKyun Na¹  Vivek K Bajpai²  Yong-Ha Park²  Sun Chul Kang³ 

[1] College of Pharmacy, Chungnam National University, 305-764, Daejeon, Korea;Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, 712-749, Gyeongsan, Gyeongbuk, Korea;Department of Biotechnology, Daegu University, 712-714, Gyeongsan, Gyeongbuk, Korea;

关键词: Metasequoia glyptostroboides;    Taxoquinone;    α-Glucosidase;    Tyrosinase;    Terpenoids;   

DOI  :  10.1186/s12906-015-0626-3

 received in 2014-10-01, accepted in 2015-03-18,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNowadays plant derived natural compounds have gained huge amount of research attention especially in food and medicine industries due to their multitude of biological and therapeutic properties as alternative medicines.MethodsIn this study, a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides was evaluated for its α–glucosidase and tyrosinase inhibitory efficacy in terms of its potent anti-diabetic and depigmentation potential, respectively.ResultsAs a result, taxoquinone at the concentration range of 100–3,000 μg/mL and 200–1,000 μg/mL showed potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively.ConclusionsThe findings of this study clearly evident potent therapeutic efficacy of an abietane diterpenoid taxoquinone isolated from M. glyptostroboides with a possibility for using it as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent.

【 授权许可】

Unknown   
© Bajpai et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.