Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

BMC Research Notes

Adrian F Gombart¹  Niels Borregaard³  Balz Frei¹  John Cuomo²  Toni McKinnon²  Tyler Barker⁴  Brian M Dixon² 

[1] Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA;USANA Health Sciences, Inc, 3838 West Parkway Boulevard, Salt Lake City, UT 84120, USA;The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, Copenhagen, Denmark;Sport Science Department, The Orthopedic Specialty Hospital, Murray, UT 84107, USA

关键词: Infection;    CAMP;    Plasma;    Serum;    Immunity;    LL-37;    hCAP18;    Cathelicidin;    25-hydroxyvitamin D;    Vitamin D;   

Others  :  1165439
DOI  :  10.1186/1756-0500-5-575

 received in 2012-09-06, accepted in 2012-10-19,  发布年份 2012

【 摘 要 】

Background

Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against infection and/or sepsis. We hypothesized that serum vitamin D levels may modulate the circulating levels of hCAP18. Only three studies have shown a positive correlation between circulating 25-hydroxyvitamin D and hCAP18 levels. Here we provide additional evidence for such a correlation in healthy, middle-aged adults.

Findings

Serum levels of 25-hydroxyvitamin D [25(OH)D] and plasma levels of hCAP18 were determined in 19 healthy middle-aged (mean of 50.1 years) adult men and women. Plasma hCAP18 concentrations correlated with serum 25(OH)D concentrations in subjects with 25(OH)D levels ≤ 32 ng/ml (r = 0.81, p < 0.005) but not in subjects with concentrations > 32 ng/ml (r = 0.19, p = 0.63).

Conclusions

We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D ≤ 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37.

【 授权许可】

   
2012 Dixon et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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