BMC Research Notes | |
Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults | |
关键词: Vitamin D; 25-hydroxyvitamin D; Cathelicidin; hCAP18; LL-37; Immunity; Serum; Plasma; CAMP; Infection; | |
DOI : 10.1186/1756-0500-5-575 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Transcription of the cathelicidin antimicrobial peptide (
Findings
Serum levels of 25-hydroxyvitamin D [25(OH)D] and plasma levels of hCAP18 were determined in 19 healthy middle-aged (mean of 50.1 years) adult men and women. Plasma hCAP18 concentrations correlated with serum 25(OH)D concentrations in subjects with 25(OH)D levels ≤ 32 ng/ml (r = 0.81, p < 0.005) but not in subjects with concentrations > 32 ng/ml (r = 0.19, p = 0.63).
Conclusions
We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D ≤ 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37.
【 授权许可】
Unknown