Diet, occupational exposure and early asthma incidence among bakers, pastry makers and hairdressers

BMC Public Health

Denis Zmirou-Navier²  Christophe Paris¹  Dovi-Stéphanie Acouetey¹  Thomas Rémen³ 

[1] Lorraine University Medical School, Nancy, France;EHESP School of Public Health, Sorbonne-Paris Cité, Rennes, France;INSERM U954, Faculté de Médecine, Bâtiment E, 2ème étage, 9 avenue de la forêt de Haye, 54505, VANDOEUVRE-LES-NANCY, France

关键词: Vitamins;    Atopy;    Epidemiology;    Occupational asthma;   

Others  :  1163588
DOI  :  10.1186/1471-2458-12-387

 received in 2011-12-16, accepted in 2012-05-29,  发布年份 2012

【 摘 要 】

Background

The natural history of occupational asthma (OA) is influenced by many determinants. This study aims to assess the combined roles of personal characteristics, including occupational exposure and nutritional habits, on the incidence of OA during the first years at work.

Methods

A nested case–control study was conducted within a retrospective cohort of young workers in the bakery, pastry-making and hairdressing sectors. Cases were subjects diagnosed as ‘confirmed’ or ‘probable’ OA consecutively to a medical visit (N = 31). Controls were subjects without OA (N = 196). Atopy was defined after blood specific IgE analysis, based on the Phadiatop^TM test. Occupational exposure was characterized by standardized questionnaires and diet patterns by a food frequency questionnaire.

Results

Among bakers and pastry-makers, only atopy is an independent risk factor of OA (OR = 10.07 95%CI [2.76 – 36.65]). Among hairdressers, several variables are associated with OA. Body mass index (unit OR = 1.24 [1.03 – 1.48]) and the score of exposure intensity (unit OR = 1.79 [1.05 – 3.05]) are independent predictors of OA, but the role of atopy is weak (OR = 4.94 [0.66 – 36.75]). Intake of vitamin A is higher among hairdressers cases (crude p = 0.002, adjusted p = 0.01 after control for body mass index and atopy); the same observation is made for vitamin D (crude p = 0.004, adjusted p = 0.01).

Conclusion

This study suggests that the influence of several factors on the incidence of OA, including dietary vitamins, might vary across exposure settings.

【 授权许可】

   
2012 Rémen et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Bernstein IL, Bernstein DI, Chan-Yeung M, Malo J-L: Definition and classification of asthma in the workplace. In asthma in the workplace. 3rd edition. Edited by Bernstein L, Chan-Yeung M, Malo J-L, Bernstein DI. Taylor & Francis Group, New York; 2006:1-8.
• [2]Mapp CE, Boschetto P, Maestrelli P, Fabbri LM: Occupational asthma: state of art. Am J Respir Crit Care Med 2005, 172:280-305.
• [3]Malo JL, Ghezzo H, D’Aquino C, L’Archevêque J, Cartier A, Chan-Yeung M: Natural history of occupational asthma: relevance of type of agent and other factors in the rate of development of symptoms in affected subjects. J Allergy Clin Immunol 1992 Dec, 90(6 Pt 1):937-944.
• [4]Black PN, Sharpe S: Dietary fat and asthma: is there a connection? Eur Respir J 1997 Jan, 10(1):6-12.
• [5]Allan K, Devereux G: Diet and asthma: nutrition implications from prevention to treatment. J Am Diet Assoc 2011 Feb, 111(2):258-268.
• [6]Nurmatov U, Devereux G, Sheikh A: Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 2011 Mar, 127(3):724-733. e1-30. Epub 2010 Dec 24
• [7]Gu H, Itoh M, Matsuyama N, Hayashi S, Iimura A, Nakamura Y, Miki T, Takeuchi Y: Toluene diisocyanate exposure induces laryngo-tracheal eosinophilia, which can be ameliorated by supplementation with antioxidant vitamins in guinea pigs. Acta Otolaryngol 2003 Oct, 123(8):965-971.
• [8]Gautrin D, Newman-Taylor AJ, Nordman H, Malo JL: Controversies in epidemiology of occupational asthma. Eur Respir J 2003 Sep, 22(3):551-559.
• [9]Rémen T, Coevoet V, Acouetey DS, Guéant JL, Guéant-Rodriguez RM, Paris C, Zmirou-Navier D: Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study. BMC Publ Health 2010 Apr 26, 10:206. BioMed Central Full Text
• [10]Rémen T, Acouetey DS, Paris C, Hannhart B, Poussel M, Chenuel B, Barbaud A, Zmirou-Navier D: Early incidence of occupational asthma in the bakery, pastry and hairdressing sectors. Prim Care Respir J 2006, 15(1):20-34.
• [11]Levy ML, Fletcher M, Price DB, Hausen T, Halbert RJ, Yawn BP: International Primary Care Respiratory Group (IPCRG) Guidelines: diagnosis of respiratory diseases in primary care. Prim Care Respir J 2006 Feb, 15(1):20-34.
• [12]Kauffmann F, Annesi-Maesano I, Liard R, Paty E, Faraldo B, Neukirch F, et al.: Construction and validation of a respiratory epidemiological questionnaire. Rev Mal Respir 2002 Jun, 19(3):323-333.
• [13]Delclos GL, Arif AA, Aday L, Carson A, Lai D, Lusk C, et al.: Validation of an asthma questionnaire for use in healthcare workers. Occup Environ Med 2006 Mar, 63(3):173-179.
• [14]Vandenplas O, Ghezzo H, Munoz X, Moscato G, Perfetti L, Lemiere C, et al.: What are the questionnaire items most useful in identifying subjects with occupational asthma? Eur Respir J 2005 Dec, 26(6):1056-1063.
• [15]Vidal C, Gude F, Boquete O, Fernandez-Merino MC, Meijide LM, Rey J, et al.: Evaluation of the phadiatop test in the diagnosis of allergic sensitization in a general adult population. J Investig Allergol Clin Immunol 2005, 15(2):124-130.
• [16]Mounier-Geyssant E, Barthelemy JF, Mouchot L, Paris C, Zmirou-Navier D: Exposure of bakery and pastry apprentices to airborne flour dust using PM2.5 and PM10 personal samplers. BMC Publ Health 2007, 7:311. BioMed Central Full Text
• [17]Mounier-Geyssant E, Oury V, Mouchot L, Paris C, Zmirou-Navier D: Exposure of hairdressing apprentices to airborne hazardous substances. Environ Health 2006, 5:23. BioMed Central Full Text
• [18]Kesse-Guyot E, Castetbon K, Touvier M, Hercberg S, Galan P: Relative validity and reproducibility of a food frequency questionnaire designed for French adults. Ann Nutr Metab 2010, 57(3–4):153-162. Epub 2010 Nov 16
• [19]Akpinar-Elci M, Cimrin AH, Elci OC: Prevalence and risk factors of occupational asthma among hairdressers in Turkey. J Occup Environ Med 2002, 44:585-590.
• [20]Albin M, Rylander L, Mikoczy Z, Lillienberg L, Dahlman Hoglund A, Brisman J, et al.: Incidence of asthma in female Swedish hairdressers. Occup Environ Med 2002 Feb, 59(2):119-123.
• [21]Brisman J, Jarvholm B, Lillienberg L: Exposure-response relations for self reported asthma and rhinitis in bakers. Occup Environ Med 2000 May, 57(5):335-340.
• [22]Cullinan P, Cook A, Nieuwenhuijsen MJ, et al.: Allergen and dust exposure as determinants of work-related symptoms and sensitization in a cohort of flour-exposed workers; a case–control analysis. Ann Occup Hyg 2001, 45:97-103.
• [23]Mounier-Geyssant E, Barthélemy JF, Mouchot L, Paris C, Zmirou-Navier D: Exposure of bakery and pastry apprentices to airborne flour dust using PM2.5 and PM10 personal samplers. BMC Publ Health 2007 Nov 1, 7:311. BioMed Central Full Text
• [24]Camargo CA, Weiss ST, Zhang S, Willett WC, Speizer FE: Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999 Nov 22, 159(21):2582-2588.
• [25]Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD: Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001 May, 163(6):1344-1349.
• [26]Chinn S, Jarvis D, Burney P: Relation of bronchial responsiveness to body mass index in the ECRHS. European Community Respiratory Health Survey. Thorax 2002 Dec, 57(12):1028-1033.
• [27]Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, et al.: Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol 2003 Sep 1, 158(5):406-415.
• [28]Gold DR, Damokosh AI, Dockery DW, Berkey CS: Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol 2003 Dec, 36(6):514-521.
• [29]Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD: Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med 2004 Jul 1, 170(1):78-85.
• [30]Oddy WH, Sherriff JL, de Klerk NH, Kendall GE, Sly PD, Beilin LJ, et al.: The relation of breastfeeding and body mass index to asthma and atopy in children: a prospective cohort study to age 6 years. Am J Public Health 2004 Sep, 94(9):1531-1537.
• [31]Romieu I, Avenel V, Leynaert B, Kauffmann F, Clavel-Chapelon F: Body mass index, change in body silhouette, and risk of asthma in the E3N cohort study. Am J Epidemiol 2003 Jul 15, 158(2):165-174.
• [32]Schaub B, von Mutius E: Obesity and asthma, what are the links? Curr Opin Allergy Clin Immunol 2005 Apr, 5(2):185-193.
• [33]McLachlan CR, Poulton R, Car G, Cowan J, Filsell S, Greene JM, Taylor DR, Welch D, Williamson A, Sears MR, Hancox RJ: Adiposity, asthma, and airway inflfl ammation. J Allergy Clin Immunol 2007 Mar, 119(3):634-639.
• [34]Moscato G, Galdi E: Asthma and hairdressers. Curr Opin Allergy Clin Immunol 2006 Apr, 6(2):91-95.
• [35]Romieu I, Trenga C: Diet and obstructive lung diseases. Epidemiol Rev 2001, 23(2):268-287.
• [36]Seaton A, Godden DJ, Brown K: Increase in asthma: A more toxic environment or a more susceptible population? Thorax 1994, 49:171-174.
• [37]Murr C, Schroecksnadel K, Winkler C, Ledochowski M, Fuchs D: Antioxidants may increase the probability of developing allergic diseases and asthma. Med Hypotheses 2005, 64(5):973-977.
• [38]Romieu I: Nutrition and lung health. Int J Tuberc Lung Dis 2005 Apr, 9(4):362-374.
• [39]Litonjua AA, Weiss ST: Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007, 120:1031-1035.
• [40]Lemire JM, Archer DC, Beck L, Spiegelberg HL: Immunosuppressive actions of 1,25-dihydroxy vitamin D3: preferential inhibition of Th1 functions. J Nutr 1995, 125(suppl):1704S-1708S.
• [41]Jirapongsananuruk O, Melamed I, Leung DY: Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and corticosteroids on TH1, but not TH2, responses. J Allergy Clin Immunol 2000, 106:981-985.
• [42]Lehouck A, Mathieu C, Bouillon R, Verhaegen J, Van Eldere J, Decallonne B, Carremans C, Baeke F, Decramer M, Janssens W: High doses of vitamin D for the treatment of COPD exacerbations: an intervention trial. Am J Respir Crit Care Med 2011, 183:A5372.
• [43]Molag ML, de Vries JH, Ocké MC, Dagnelie PC, van den Brandt PA, Jansen MC, van Staveren WA, van’t Veer P: Design characteristics of food frequency questionnaires in relation to their validity. Am J Epidemiol 2007 Dec 15, 166(12):1468-1478. Epub 2007 Sep 18