Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study

Environmental Health

Research

Malene Thygesen¹  Preben Bo Mortensen²  Diana E. Schendel³  Igor Burstyn⁴  Alison B. Singer⁵  M. Daniele Fallin⁶ 

[1] Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark;Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210, Aarhus V, Denmark;Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark;Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210, Aarhus V, Denmark;Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark;Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark;Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210, Aarhus V, Denmark;Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark;Department of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000, Aarhus C, Denmark;Department of Environmental and Occupational Health, Department of Epidemiology and Biostatistics, the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, 3215 Market Street, 19104, Philadelphia, PA, USA;Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, 21205, Baltimore, MD, USA;Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark;Department of Epidemiology, University of North Carolina at Chapel Hill, CB #7435, 27599, Chapel Hill, NC, USA;Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, 21205, Baltimore, MD, USA;Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 N. Broadway, 21205, Baltimore, MD, USA;

关键词: Epidemiology;    Neurodevelopment;    Prenatal exposure;    Occupational asthma;    Autism;   

DOI  :  10.1186/s12940-017-0230-8

 received in 2016-11-08, accepted in 2017-02-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEnvironmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD. We evaluated the association between parental workplace exposures to risk factors for asthma (“asthmagens”) and ASD.MethodsWe conducted a population-based case-control study in the Danish population using register linkage. Our study population consisted of 11,869 ASD cases and 48,046 controls born from 1993 through 2007. Cases were identified by ICD-10 codes in the Danish Psychiatric Central Register. ASD cases and controls were linked to parental Danish International Standard Classification of Occupations (DISCO-88) job codes. Parental occupational asthmagen exposure was estimated by linking DISCO-88 codes to an asthma-specific job-exposure matrix.ResultsOur maternal analyses included 6706 case mothers and 29,359 control mothers employed during the pregnancy period. We found a weak inverse association between ASD and any maternal occupational asthmagen exposure, adjusting for sociodemographic covariates (adjusted OR: 0.92, 95% CI: 0.86–0.99). In adjusted analyses, including 7647 cases and 31,947 controls with employed fathers, paternal occupational asthmagen exposure was not associated with ASD (adjusted OR: 0.98, 95% CI: 0.92–1.05).ConclusionsWe found a weak inverse association between maternal occupational asthmagen exposure and ASD, and a null association between paternal occupational exposure and ASD. We suggest that unmeasured confounding negatively biased the estimate, but that this unmeasured confounding is likely not strong enough to bring the effect above the null. Overall, our results were consistent with no positive association between parental asthmagen exposure and ASD in the children.

【 授权许可】

CC BY   
© The Author(s). 2017