Physical activity and renal cell carcinoma among black and white Americans: a case-control study

BMC Cancer

Qian Xiao⁴  Linda Liao⁴  Charles E Matthews⁴  Wong-Ho Chow²  Faith Davis³  Kendra Schwartz¹  Mark Purdue⁴  Jonathan N Hofmann⁴  Joanne Colt⁴ 

[1] Karmanos Cancer Institute and Department of Family Medicine & Public Health Sciences, Wayne State University, Detroit, MI, USA

[2] Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

[3] School of Public Health, University of Alberta, Alberta, Canada

[4] Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

关键词: Case-control study;    Racial differences;    Physical activities;    Renal cell carcinoma;   

Others  :  1121033
DOI  :  10.1186/1471-2407-14-707

 received in 2014-01-29, accepted in 2014-09-16,  发布年份 2014

【 摘 要 】

Background

Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated this relationship in the black population.

Methods

We examined the association between self-reported physical activity at different ages and risk of RCC in a population based case-control study of 1217 cases (361 black, 856 white) and 1235 controls (523 black, 712 white) frequency-matched on age, race, and gender. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression.

Results

Among whites, increased risks of RCC were observed among participants reporting low levels of transportation-related activity in their 20’s (OR _{<1 hr/wk vs >7 hr/wk} (95% CI): 1.42 (1.10, 1.83)) and leisure time activity in their 50’s (OR _{<1 hr/wk vs >7 hr/wk} (95% CI): 1.49 (1.00, 2.20)). We found no association between physical activity and RCC risk among blacks.

Conclusion

Our results suggest that physical activity may be inversely associated with RCC risk in whites, but there was no evidence of such an association in blacks. As this is the first study evaluating the effect of physical activity on RCC risk among blacks, further investigations are needed to clarify the relationship in this population.

【 授权许可】

   
2014 Xiao et al.; licensee BioMed Central Ltd.

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