Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity

BMC Complementary and Alternative Medicine

Youn Jung Kim²  Dae-Ok Kim¹  Young-Eun Kim¹  Tae-Gyu Nam¹  Jeong-Moon Yun³  Sung-Hyun Park³  Hee Kang³ 

[1] Department of Food Science and Biotechnology, College of Life Sciences, KyungHee University, Yongin, South Korea;College of Nursing Science, KyungHee University, Seoul, South Korea;Department of East-west Medical Science, Graduate School of East-west Medical Science, KyungHee University, Yongin, South Korea

关键词: Atherosclerosis;    Scavenger receptor;    Macrophages;    Monocytes;    Cinnamon water extract;   

Others  :  1220233
DOI  :  10.1186/1472-6882-14-90

 received in 2013-10-05, accepted in 2014-02-28,  发布年份 2014

【 摘 要 】

Background

Water soluble cinnamon extract has been shown to increase insulin sensitivity and modulate macrophage activation, a desirable trait for the management of obesity or atherosclerosis. Our present study investigated whether cinnamon water extract (CWE) may influence the differentiation of monocytes into macrophages and the activity of macrophage scavenger receptors, commonly observed in atherosclerotic lesions.

Methods

We investigated the effect of CWE on the expression of various surface markers and the uptake of acetylated low density lipoprotein (LDL) in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 cells. The protein levels of PMA or macrophage-colony stimulating factor (M-CSF)-stimulated type 1 macrophage scavenger receptor (SRA) were analyzed. Finally, the role of extracellar signal-related kinase (ERK) 1/2 in SRA synthesis and the effect of CWE on PMA-stimulated ERK1/2 were determined.

Results

CWE inhibited the differentiation of monocyte by decreasing the expression of CD11b, CD36 and SRA and the uptake of acetyl LDL. CWE suppressed the upregulation of SRA by M-CSF and modulated ERK1/2 activity, which was required for PMA-induced SRA synthesis.

Conclusions

Our results demonstrate that CWE was able to interfere with monocyte differentiation and macrophage scavenger activity, indicating its potential in preventing the development of atherosclerotic lesions.

【 授权许可】

   
2014 Kang et al.; licensee BioMed Central Ltd.

【 图 表 】

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