The incidence and aetiology of hospitalised community-acquired pneumonia among Vietnamese adults: a prospective surveillance in Central Vietnam

BMC Infectious Diseases

Lay Myint Yoshida²  Koya Ariyoshi²  Dang Duc Anh³  Paul E Kilgore¹  Konosuke Morimoto²  Le Huu Tho⁴  Nguyen Thi Thuy Ai⁵  Phan The Long⁵  Tran Vo Vinh Son⁵  Luu Thi Minh Huong⁵  Nguyen Hien Anh³  Le Nhat Minh²  Motoi Suzuki²  Kensuke Takahashi² 

[1] Wayne State University, 5057, Woodward Avenue #3101, Detroit, MI, USA;Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan;National Institute of Hygiene and Epidemiology, 1 Yersin, Hai Ba Trung, Hanoi, Vietnam;Khanh Hoa Health Service, 3 Han Thuyen, Nha Trang, Khanh Hoa, Vietnam;Khanh Hoa General Hospital, 19 Yersin, Loc Tho, Nha Trang, Khanh Hoa, Vietnam

关键词: Multiplex PCR;    Nasopharyngeal swab;    Viral pneumonia;    Vietnam;    Southeast Asia;    Ageing;    Incidence;    Aetiology;    Community-acquired pneumonia;   

Others  :  1147277
DOI  :  10.1186/1471-2334-13-296

 received in 2012-09-28, accepted in 2013-06-20,  发布年份 2013

【 摘 要 】

Background

Lower respiratory tract infection (LRTI) including Community-acquired pneumonia (CAP) is a common infectious disease that is associated with significant morbidity and mortality. The patterns of aetiological pathogens differ by region and country. Special attention must be paid to CAP in Southeast Asia (SEA), a region facing rapid demographic transition. Estimates burden and aetiological patterns of CAP are essential for the clinical and public health management. The purposes of the study are to determine the incidence, aetiological pathogens, clinical pictures and risk factors of community-acquired pneumonia (CAP) in the Vietnamese adult population.

Methods

A prospective surveillance for hospitalised adult CAP was conducted in Khanh Hoa Province, Central Vietnam. All adults aged ≥15 years with lower respiratory tract infections (LRTI) admitted to a provincial hospital from September 2009 to August 2010 were enrolled in the study. Patients were classified into CAP and non-pneumonic LRTI (NPLRTI) according to the radiological findings. Bacterial pathogens were identified from sputum samples by the conventional culture and polymerase chain reaction (PCR) for Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis; 13 respiratory viruses were identified from nasopharyngeal specimens by PCR.

Results

Of all 367 LRTI episodes examined, 174 (47%) were CAP. Older age, the presence of underlying respiratory conditions, and higher index score of smoking were associated with CAP. The one-year estimated incidence of hospitalised adult CAP in our study population was 0.81 per 1,000 person years. The incidence increased considerably with age and was highest among the elderly. The case fatality proportion of hospitalised CAP patients was 9.8%. Among 286 sputum samples tested for bacterial PCR, 79 (28%) were positive for H. influenzae, and 65 (23%) were positive for S. pneumoniae. Among 357 samples tested for viral PCR, 73 (21%) were positive for respiratory viruses; influenza A (n = 32, 9%) was the most common.

Conclusions

The current adult CAP incidence in Vietnam was relatively low; this result was mainly attributed to the young age of our study population.

【 授权许可】

   
2013 Takahashi et al.; licensee BioMed Central Ltd.

【 图 表 】

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