Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies

BMC Psychiatry

Samantha J Brooks¹  Helgi B Schiöth¹  Olof C Hjorth¹  Olga E Titova¹ 

[1] Department of Neuroscience, Uppsala University, Box 593, Husargatan 3, Uppsala, Sweden

关键词: Cerebrospinal fluid;    White matter;    Gray matter;    Anorexia nervosa;    ALE;    VBM;   

Others  :  1124084
DOI  :  10.1186/1471-244X-13-110

 received in 2012-12-14, accepted in 2013-04-03,  发布年份 2013

【 摘 要 】

Background

Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.

Methods

In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.

Results

Anorexia nervosa (AN) patients have global reductions in gray (effect size = −0.66) and white matter (effect size = −0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.

Conclusions

Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.

【 授权许可】

   
2013 Titova et al.; licensee BioMed Central Ltd.

【 图 表 】

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