Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies

BMC Psychiatry

Research Article

Samantha J Brooks¹  Olga E Titova¹  Helgi B Schiöth¹  Olof C Hjorth¹ 

[1] Department of Neuroscience, Uppsala University, Box 593, Husargatan 3, Uppsala, Sweden;

关键词: VBM;    ALE;    Anorexia nervosa;    Gray matter;    White matter;    Cerebrospinal fluid;   

DOI  :  10.1186/1471-244X-13-110

 received in 2012-12-14, accepted in 2013-04-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundStructural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.MethodsIn global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.ResultsAnorexia nervosa (AN) patients have global reductions in gray (effect size = −0.66) and white matter (effect size = −0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.ConclusionsGlobal and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.

【 授权许可】

Unknown   
© Titova et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.