Oligodendrogenesis and neurogenesis in remyelination in the cuprizone model of multiple sclerosis: correlation with the degree of lesion

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Pishchelko, A.^1 ; Khodanovich, M.^1 ; Pan, E.^1 ; Glazacheva, V.^1 ; Akulov, A.^1,2 ; Yarnykh, V.^1,3

Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^1

Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia^2

Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle

WA, United States^3

关键词: Control values;    Corpus callosum;    Gray matter;    Multiple sclerosis;    Negative correlation;    Neurogenesis;    Oligodendrocytes;    Remyelination;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012013/pdf
DOI  :  10.1088/1742-6596/886/1/012013

学科分类：卫生学

来源: IOP

【 摘 要 】

In this research, a cuprizone model of multiple sclerosis (MS) was used to study oligodendrogenesis and neurogenesis in remyelination. It has been shown that, with the administration of cuprizone, the amount of myelin in a number of structures of white and gray matter and the level of neurogenesis decrease, while the level of oligodendrogenesis increases. The withdrawal of cuprizone leads to the restoration of myelin content, the reduction of the excessive production of oligodendrocytes and to the restoration of the number of neurons to control values. The negative correlation between the number of oligodendrocyte precursors (OPCs) and the degree of demyelination of the corpus callosum indicates migration of OLG precursors from the subventricular zone (SVZ) to the structure during demyelination.