Diabetes mellitus suppresses hemodialysis-induced increases in tear fluid secretion

BMC Research Notes

Shizuya Saika⁵  Katsuo Tomoyose⁵  Peter S Reinach²  Takashi Shigematsu⁴  Hirotsugu Kobata³  Yuka Okada⁵  Motoko Nakata¹ 

[1] Department of Ophthalmology, Kihoku Bun-in Hospital, Wakayama Medical University School of Medicine, 219 Myouji, Katsuragicho, Wakayama 649-7113, Itogun, Japan;Biological Sciences, State University of New York, State College of Optometry, 33 West 42nd Street, New York, NY 10036, USA;Nate Private Hospital, 294-1, Nateichiba, Kinokawa City 649-6631, Wakayama, Japan;Department of Nephrology, Wakayama Medical University School of Medicine, 811-1, Kimiidera, Wakayama City 641-8509, Wakayama, Japan;Department of Ophthalmology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama City 641-8509, Wakayama, Japan

关键词: Diabetes mellitus;    Hemodialysis;    Tear;   

Others  :  1134600
DOI  :  10.1186/1756-0500-7-78

 received in 2013-10-15, accepted in 2014-01-31,  发布年份 2014

【 摘 要 】

Background

Hemodialysis is essential for the survival of patients suffering from chronic renal failure. However, in diabetics the incidence of dry eye disease is higher than in non-diabetic individuals. Accordingly, we evaluated if this difference is attributable to different effects of hemodialysis on basal tear fluid secretion.

Methods

A modified Schirmer´s eye test determined if hemodialysis improved basal tear secretion rates in 36 diabetic and non-diabetic patients undergoing hemodialysis.

Results

Basal tear secretion was invariant in diabetic patients whereas in non-diabetic individuals this process increased.

Conclusion

In non-diabetic patients, autonomic neuropathy appears to be less severe and somewhat reversible since only in these individuals hemodialysis improved basal tear fluid secretion. This difference may be a factor contributing to the lower incidence of dry eye disease in non-diabetic patients.

【 授权许可】

   
2014 Nakata et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Patel N, Dalal P, Panesar M: Dialysis disequilibrium syndrome: a narrative review. Semin Dial 2008, 20:493-498.
• [2]Bachleda P, Utikal P, Kalinova L, Kocher M, Cerna M, Kolar M, Zadrazil J: Infectious complications of arteriovenous ePTFE grafts for hemodialysis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010, 154:13-19.
• [3]Coppolino G, Ludisano G, Bolignano D, Buemi M: Acute cardiovascular complications of hemodialysis. Minerva Urol Nefrol 2010, 62:67-80.
• [4]Ewing DJ, Winney R: Autonomic function in patients with chronic renal failure on intermittent hemodialysis. Nephron 1975, 15:424-429.
• [5]Campese VM, Romoff MS, Levitan D, Lane K, Massry SG: Mechanism of autonomic nervous system dysfunction in uremia. Kidney Int 1981, 20:246-253.
• [6]Cengic B, Resic H: Depression in hemodialysis patients. Bosn J Basic Med Sci 2010, 10:S73-S78.
• [7]Yeh SM, Hwang SJ, Chen HC: Treatment of severe metastatic calcification in hemodialysis patients. Hemodial Int 2009, 13:163-167.
• [8]Evans RD, Rosner M: Ocular abnormalities associated with advanced kidney disease and hemodialysis. Semin Dial 2005, 18:252-257.
• [9]Doshiro A, Ban Y, Kobayashi L, Yoshida Y, Uchiyama H: Intraocular pressure change during hemodialysis. Am J Ophthalmol 2006, 142:337-339.
• [10]Broekema N, van Bijsterveld OP, de Bos Kuil RJ: Intraocular pressure during hemodialysis. Ophthlmologica 1988, 197:60-64.
• [11]Masuda H, Shibuya Y, Ohira A: Markedly increased unilateral intraocular pressure during hemodialysis in a patient with ipsilateral exfoliative glaucoma. Am J Ophthalmol 2000, 129:534-536.
• [12]Tawara A, Kobata H, Fujisawa K, Abe T, Ohnishi Y: Mechanism of intraocular pressure elevation during hemodialysis. Curr Eye Res 1998, 17:339-347.
• [13]Tokuyama T, Ikeda T, Sato K: Effect of haemodialysis on diabetic macular leakage. Br J Ophthalmol 2000, 84:1397-1400.
• [14]Aktas Z, Ozdek S, Asli Dinc U, Akyürek N, Atalay V, Güz G, Hasanreisoglu B: Alterations in ocular surface and corneal thickness in relation to metabolic control in patients with chronic renal failure. Nephrology (Carlton) 2007, 12(380):385.
• [15]Ozdemir M, Bakaris S, Ozdemir G, Buyukbese MA, Cetinkaya A: Ocular surface disorders and tear function changes in patients with chronic renal failure. Can J Ophthalmol 2004, 39:526-532.
• [16]Charlton JF, Schwab IR, Stuchell R: Tear hyperosmolarity in renal dialysis patients asymptomatic for dry eye. Cornea 1996, 15:335-339.
• [17]Hoshino M, Tane S, Hoshino T, Ishida M: Schirmer test in patients undergoing hemodialysis. Rinsho Ganka 1994, 48:295-297.
• [18]Akinci A, Cetinkaya E, Aycan Z: Dry eye syndrome in diabetic children. Eur J Ophthalmol 2007, 17:873-878.
• [19]Cousen P, Cackett P, Bennett H, Swa K, Dhillon B: Tear production and corneal sensitivity in diabetes. J Diabetes Complications 2007, 21:371-373.
• [20]Walcott B: The lacrimal gland and its veil of tears. News Physiol Sci 1998, 13:97-103.
• [21]Dartt DA: Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res 2009, 28:155-177.
• [22]Hodges RR, Bair JA, Carozza RB, Li D, Shatos MA, Dartt DA: Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res 2012, 103:99-113.
• [23]Augustyniak RA, Tuncel M, Zhang W, Toto RD, Victor RG: Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens 2002, 20:3-9.
• [24]Zilch O, Vos PF, Oey PL, Cramer MJ, Ligtenberg G, Koomans HA, Blankestijn PJ: Sympathetic hyperactivity in haemodialysis patients is reduced by short daily haemodialysis. J Hypertens 2007, 25:1285-1289.
• [25]Giordano M, Manzella D, Paolisso G, Caliendo A, Varricchio M, Giordano C: Difference in heart rate variability parameters during the post –dialytic period in type II diabetic and non-diabetic ESRD patients. Nephrol Dial Transplant 2001, 16:566-573.
• [26]Ewing DJ, Clarke BF: Diagnosis and management of diabetic autonomic neuropathy. Br Med J 1982, 285:916-918.
• [27]Ewing DJ, Martyn CN, Young RJ, et al.: The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985, 8:491-498.