Serological markers of Bornavirus infection found in horses in Iceland

Acta Veterinaria Scandinavica

Sigríður Björnsdóttir¹  Elfa Agustsdóttir³  Anne-Lie Blomström⁴  Inga-Lena Örde Öström⁵  Louise Treiberg Berndtsson⁵  Vilhjálmur Svansson⁶  Jonas Johansson Wensman² 

[1] Icelandic Food and Veterinary Authority, Austurvegur 64, IS-800 Selfoss, Iceland

[2] Department of Clinical Sciences, Swedish University of Agricultural Sciences, P.O. Box 7054, SE-750 07 Uppsala, Sweden

[3] Logmannshild Veterinary Clinic, IS-603 Akureyri, Iceland

[4] Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, SE-750 07 Uppsala, Sweden

[5] Department of Virology, Immunobiology and Parasitology, National Veterinary Institute, SE-751 89 Uppsala, Sweden

[6] Institute for Experimental Pathology, University of Iceland, Keldur, IS-112 Reykjavik, Iceland

关键词: Horse;    Epidemiology;    Serology;    Neurological disease;    Borna disease;   

Others  :  789243
DOI  :  10.1186/1751-0147-55-77

 received in 2013-04-10, accepted in 2013-10-21,  发布年份 2013

【 摘 要 】

Background

In a stable of eight horses in Northern Iceland, six horses presented with clinical signs, such as ataxia and reduced appetite, leading to euthanasia of one severely affected horse. Serological investigations revealed no evidence of active equine herpes virus type 1 infection, a common source of central nervous system disease in horses, nor equine arteritis virus and West Nile virus. Another neurotropic virus, Borna disease virus, was therefore included in the differential diagnosis list.

Findings

Serological investigations revealed antibodies against Borna disease virus in four of five horses with neurological signs in the affected stable. One horse without clinical signs was seronegative. Four clinically healthy horses in the stable that arrived and were sampled one year after the outbreak were found seronegative, whereas one of four investigated healthy horses in an unaffected stable was seropositive.

Conclusions

This report contains the first evidence of antibodies to Borna disease virus in Iceland. Whether Borna disease virus was the cause of the neurological signs could however not be confirmed by pathology or molecular detection of the virus. As Iceland has very restricted legislation regarding animal imports, the questions of how this virus has entered the country and to what extent markers of Bornavirus infection can be found in humans and animals in Iceland remain to be answered.

【 授权许可】

   
2013 Björnsdóttir et al.; licensee BioMed Central Ltd.

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