Green synthesis of a typical chiral stationary phase of cellulose-tris(3, 5-dimethylphenylcarbamate)

Chemistry Central Journal

Run-Qiang Liu¹  Lian-yang Bai²  Yi-Jun Zhang¹  Yu-Ping Zhang¹ 

[1] Henan Institute of Science and Technology, Xinxiang 453003, P.R. China

[2] Hunan Academy of Agricultural Sciences, Changsha 410125, P.R. China

关键词: Chiral separation;    Pesticides;    Chiral stationary phase;    HPLC;    AmimCl;    Ionic liquid;   

Others  :  787864
DOI  :  10.1186/1752-153X-7-129

 received in 2013-04-02, accepted in 2013-06-11,  发布年份 2013

【 摘 要 】

Background

At present, the study on the homogeneous-phase derivatization of cellulose in ionic liquid is mainly focused on its acetylation. To the best of our knowledge, there has been no such report on the preparation of cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC) with ionic liquid 1-allyl-3-methyl-imidazolium chloride (AmimCl) so far.

Results

With ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl) as a reaction solvent, cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC) was synthesized by the reaction of 3,5-dimethylphenyl isocyanate and soluble microcrystalline cellulose in a homogeneous phase. The synthesized CDMPC was then coated onto the surfaces of aminopropyl silica gel to prepare a chiral stationary phase (CSP). The prepared CSP was successfully used in chiral separation of seven racemic pesticides by high performance liquid chromatography (HPLC). Good chiral separation was obtained using n-hexane and different modifiers as the mobile phases under the optimal percentage and column temperature, with the resolution of metalaxyl, diniconazole, flutriafol, paclobutrazol, hexaconazole, myclobutanil and hexythiazox of 1.73, 1.56, 1.26, 1.00, 1.18, 1.14 and 1.51, respectively. The experimental results suggested it was a good choice using a green solvent of AmimCl for cellulose functionalization.

Conclusion

CDMPC was successfully synthesized as the chiral selector by reacting 3, 5-dimethylphenyl isocyanate with dissolved microcrystalline cellulose in a green ionic liquid of AmimCl.

【 授权许可】

   
2013 Liu et al.; licensee Chemistry Central Ltd.

【 图 表 】

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