Chiral separation using hybrid of preferential crystallization moderated by a membrane barrier

Crystallization;Chiral separation;Membrane separation

Svang-Ariyaskul, Apichit ; Chemical Engineering

University:Georgia Institute of Technology

Department:Chemical Engineering

关键词: Crystallization;    Chiral separation;    Membrane separation;   

Others  :  https://smartech.gatech.edu/bitstream/1853/33909/1/Svang-Ariyaskul_Apichit_201005_phd.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

The major innovation of this work is an establishment of a novel chiral separation process using preferential crystallization coupled with a membrane barrier.This hybrid process was proved to be promising from a significant increase in product yield and purity compared to existing chiral separation processes.This work sets up a process design platform to extend the use of this hybrid process to a separation of other mixtures. This novel process especially is a promising alternative for chiral separation of pharmaceutical compounds which include more than fifty percent of approved drugs world-wide.A better performance chiral separation technique contributes to cut the operating cost and to reduce the price of chiral drugs.