Physiological evaluation of free-ranging moose (Alces alces) immobilized with etorphine-xylazine-acepromazine in Northern Sweden

Acta Veterinaria Scandinavica

Alina L Evans²  Åsa Fahlman¹  Göran Ericsson⁴  Henning Andreas Haga³  Jon M Arnemo⁴ 

[1] Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada

[2] Section of Arctic Veterinary Medicine, Norwegian School of Veterinary Science, Tromsø, NO-9292, Norway

[3] Department of Clinical Sciences, Norwegian School of Veterinary Science, Oslo, NO-0033, Norway

[4] Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, SE-901 83, Sweden

关键词: Immobilization;    Xylazine;    Etorphine;    Anesthesia;    Moose;    Alces;   

Others  :  789423
DOI  :  10.1186/1751-0147-54-77

 received in 2012-06-16, accepted in 2012-12-16,  发布年份 2012

【 摘 要 】

Background

Evaluation of physiology during capture and anesthesia of free-ranging wildlife is useful for determining the effect that capture methods have on both ecological research results and animal welfare. This study evaluates capture and anesthesia of moose (Alces alces) with etorphine-xylazine-acepromazine in Northern Sweden.

Methods

Fifteen adult moose aged 3–15 years were darted from a helicopter with a combination of 3.37 mg etorphine, 75 mg xylazine, and 15 mg acepromazine. Paired arterial blood samples were collected 15 minutes apart with the first sample at 15–23 minutes after darting and were analyzed immediately with an i-STAT®1 Portable Clinical Analyzer.

Results

All animals developed hypoxemia (PaO₂ <10 kPa) with nine animals having marked hypoxemia (PaO₂ 5.5-8 kPa). All moose were acidemic (ph<7.35) with nine moose having marked acidemia (pH<7.20). For PaCO_2, 14 moose had mild hypercapnia (PaCO₂ 6-8 kPa) and two had marked hypercapnia (PaCO₂>8 kPa). Pulse, respiratory rate, pH and HCO₃ increased significantly over time from darting whereas lactate decreased.

Conclusions

The hypoxemia found in this study is a strong indication for investigating alternative drug doses or combinations or treatment with supplemental oxygen.

【 授权许可】

   
2012 Evans et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Arnemo JM, Kreeger TJ, Soveri T: Chemical immobilization of free-ranging moose. Alces 2003, 39:243-253.
• [2]Kreeger TJ, Arnemo JM: Handbook of wildlife chemical immobilization 4th ed. 3rd edition. Wheatland, Wyoming: Terry J. Kreeger; 2012.
• [3]Kreeger T, Edwards W, Wald E, Becker S, Brimeyer D, Fralick G, Berger J: Health assessment of Shiras moose immobilized with thiafentanil. Alces 2005, 41:121-128.
• [4]Arnemo JM, Ericsson G, Oen EO, Broman E, Heim M, Wallin K, Os O, Ball J: Immobilization of free-ranging moose (Alces alces) with etorphine or etorphine-acepromazine-xylazine in Scandinavia 1984–2003: A review of 2,754 captures. Proceedings AAZV, AAWV, WDA Joint Conference 2004, 2004:515-516.
• [5]Delvaux H, Courtois R, Breton L, Patenaude R: Relative efficiency of succinylcholine, xylazine, and carfentanil/xylazine mixtures to immobilize free-ranging moose. J Wildl Dis 1999, 35:38-48.
• [6]Seal US, Schmitt SM, Peterson RO: Carfentanil and xylazine for immobilization of moose (Alces alces) on Isle Royale. J Wildl Dis 1985, 21:48-51.
• [7]Cattet M, Boulanger J, Stenhouse G, Powell RA, Reynolds-Hogland MJ: An evaluation of long-term capture effects in ursids: Implications for wildlife welfare and research. J Mammal 2008, 89:973-990.
• [8]Larsen DG, Gauthier DA: Effects of capturing pregnant moose and calves on calf survivorship. J Wildl Manag 1989, 53:564-567.
• [9]Neumann W, Ericsson G, Dettki H, Arnemo J: Effect of immobilizations on female moose (Alces alces) activity and space use. Can J Zool 2011, 89:1013-1018.
• [10]Gutierrez G: Hypoxia and hypoxemia. In Encyclopedia of respiratory medicine. Edited by Geoffrey JL, Steven DS. Oxford: Academic; 2006:302-307.
• [11]Siesjö B: Acidosis and ischemic brain damage. Mol Chem Neuropathol 1988, 9:31-88.
• [12]Wang P, Ba ZF H, Chaudry I: Severe hypoxemia in the absence of blood loss depresses hepatocellular function and up-regulates IL-6 and PGE2. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1997, 1361:42-48.
• [13]Dyson A, Stidwill R, Taylor V, Singer M: Tissue oxygen monitoring in rodent models of shock. Am J Physiol Heart Circ Physiol 2007, 293:526-533.
• [14]Evans RG, Goddard D, Eppel GA, O’Connor PM: Factors that render the kidney susceptible to tissue hypoxia in hypoxemia. Am J Physiol Regul Integr Comp Physiol 2011, 300:R931-R940.
• [15]Braaksma MA, Dassel ACM, Aarnoudse JG: Renal responses to prolonged (48 h) hypoxemia without acidemia in the late-gestation ovine fetus. Am J Physiol Regul Integr Comp Physiol 1999, 277:R395-R402.
• [16]Rees S, Breen S, Loeliger M, McCrabb G, Harding R: Hypoxemia near mid-gestation has long-term effects on fetal brain development. J Neuropathol Exp Neurol 1999, 58:932-945.
• [17]Ericsson GWK: Senescence in a northern ungulate: Age and sex-specific patterns of mortality in moose. Ecoscience 2001, 8:157-163.
• [18]Jalanka HH, Roeken BO: The use of medetomidine, medetomidine-ketamine combinations, and atipamezole in nondomestic mammals: a review. J Zoo Anim Med 1990, 21:259-282.
• [19]Schmidt-Nielsen K: Animal physiology: adaptation and environment. Cambridge, England: Cambridge University Press; 1997.
• [20]Haga HA, Wenger S, Hvarnes S, Os O, Rolandsen CM, Solberg EJ: Plasma lactate concentrations in free-ranging moose (Alces alces) immobilized with etorphine. Vet Anaesth Analg 2009, 36:555-561.
• [21]Lynch GM, Hanson JA: Use of etorphine to immobilize moose. J Wildl Manag 1981, 45:981-985.
• [22]Kreeger TJ: Xylazine-induced aspiration pneumonia in Shira’s moose. Wildl Soc Bull 2000, 28:751-753.
• [23]Arnemo JM, Ahlqvist P, Andersen R, Berntsen F, Ericsson G, Odden J, Brunberg S, Segerstrom P, Swenson JE: Risk of capture-related mortality in large free-ranging mammals: experiences from Scandinavia. Wildl Biol 2006, 12:109-113.
• [24]Gustein HB, Akil H: Opioid analgesics. In Goodman & Gilman’s the pharmacological basis of therapeutics. 11th edition. Edited by Brunton LL. New York: McGraw/Hill; 2006:560-568.
• [25]Grimm KA, Lamont L: Clinical pharmacology. In Zoo animal and wildlife immobilization and anesthesi. 1st edition. Edited by West G, Heard D, Caulket N. Ames, Iowa, USA: Wiley-Blackwell; 2008:3-36.
• [26]Celly CS, Atwal OS, McDonell WN, Black WD: Histopathologic alterations induced in the lungs of sheep by use of alpha(2)-adrenergic receptor agonists. Am J Vet Res 1999, 60:154-161.
• [27]Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W: Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations. Can Vet J 2000, 41:49-53.
• [28]Caulkett NA, Cribb PH, Haigh JC: Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for Immobilization of mule deer and mule deer/white-tailed deer hybrids. Can J Vet Res 2000, 64:64-68.
• [29]Read M, Caulkett NA, Symington A, Shury TK: Treatment of hypoxemia during xylazine-tiletamine-zolazepam immobilization of wapiti. Can Vet J 2001, 42:861-864.
• [30]Storms TN, Schumacher J, Zagaya N, Osborn DA, Miller KV, Ramsay EC: Determination and evaluation of an optimal dosage of carfentanil and xylazine for the immobilization of white-tailed deer (Odocoileus virginianus). J Wildl Dis 2005, 41:559-568.
• [31]Siegal-Willott J, Citino SB, Wade S, Elder L, Hayek LA, Lance WR: Butorphanol, azaperone, and medetomidine anesthesia in free-ranging white-tailed deer (Odocoileus virginianus) using radiotransmitter darts. J Wildl Dis 2009, 45:468-480.
• [32]Paterson JM, Caulkett NA, Woodbury MR: Physiologic effects of nasal oxygen or medical air administered prior to and during carfentanil-xylazine anesthesia in North American elk (Cervus canadensis manitobensis). J Zoo Wildl Med 2009, 40:39-50.
• [33]Read MR: A review of alpha-2 adrenoreceptor agonists and the development of hypoxemia in domestic and wild ruminants. J Zoo Wildl Med 2003, 34:134-138.
• [34]West JB: Respiratory Physiology. 8th edition. Hong Kong: Lipincott Williams & Wilkins; 2008:186.
• [35]Johnson RA, Morais HA: Respiratory acid–base disorders. In Fluid, electrolyte and acid–base disorders. Edited by DiBartola SP. St. Louis, Missouri: Elsevier Inc; 2011:287-301.
• [36]Forster HV, Dempsey JA, Thomson J, Vidruk E, DoPico GA: Estimation of arterial PO2, PCO2, pH, and lactate from arterialized venous blood. J Appl Physiol 1972, 32:134-137.