Preparation of magnetite nanoparticle and fatty acid incorporated poly(methacrylic acid-ethyl acrylate) nanowebs via electrospinning for magnetic hyperthermia application

18th World Textile Conference

Sarier, N.^1 ; Onder, E.^2 ; Carvalho, M.D.^3 ; Ferreira, L.P.^4,5 ; Cruz, M.M.^5 ; Arat, R.^1

Istanbul Kultur University, Faculty of Engineering, Bakirkoy, Istanbul

34156, Turkey^1

Istanbul Technical University, Faculty of Textile Technologies and Design, Gumussuyu, Istanbul

34437, Turkey^2

CQB, Centro de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Lisboa

1749-016, Portugal^3

Department of Physics, University of Coimbra, Coimbra

3004-516, Portugal^4

BioISI, Biosystems and Integrative Sciences, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Lisboa

1749-016, Portugal^5

关键词: Acid-functionalized magnetic nanoparticles;    Alternating magnetic field;    Functionalized nanoparticles;    Magnetic hyperthermia;    Magnetic nano-particles;    Magnetic nanoparti cles (MNPs);    Repeated application;    Temperature constant;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/460/1/012025/pdf
DOI  :  10.1088/1757-899X/460/1/012025

来源: IOP

【 摘 要 】

Magnetic hyperthermia has been arising as a promising approach for treatment of cancer. When magnetic nanoparticles (MNPs) are locally injected through cancerous tissues and subjected to an appropriate alternating magnetic field, they generate heat due to the rotation of the nanomagnets, causing the destruction of the cancer cells. For repeated applications of magnetic hyperthermia, it is highly preferred to keep the temperature constant at about 41-46°C while preventing the leakage of MNPs, to minimize secondary effects on surrounding healthy tissues. In our study, we produced novel nanowebs provided with magnetic and thermal buffering properties by encapsulating MNPs and Lauric Acid in poly(methyl ethyl acrylate) matrix via uniaxial electrospinning. For the oleic acid functionalized magnetic nanoparticles, the magnetization for the corresponding nanowebs is higher by a factor of two for all concentrations than the ones with non-functionalized magnetic nanoparticles, indicating a more effective integration of the functionalized nanoparticles through the nanoweb. The heat absorption and release capacities of the nanowebs, incorporated with 1.25-2.50 % functionalized MNPs, vary between 70-75 Jg-1 at 40-48°C. They also demonstrate thermal cycling ability and thermal stability.