Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:23

Article

Passemard, Solene¹  Staedler, Davide¹  Ucnova, Lucia¹  Schneiter, Guillaume Stephane¹  Kong, Phally¹  Bonacina, Luigi²  Juillerat-Jeanneret, Lucienne^3,4  Gerber-Lemaire, Sandrine¹ 

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Synth & Nat Prod, CH-1015 Lausanne, Switzerland

[2] Univ Geneva, GAP Biophoton, CH-1211 Geneva 4, Switzerland

[3] Univ Lausanne, CHU Vaudois, CH-1011 Lausanne, Switzerland

[4] Univ Lausanne, Inst Pathol, CH-1011 Lausanne, Switzerland

关键词: Functionalized nanoparticles;    Heterotelechelic PEG oligomer;    Pegylation;    Selective monoreduction;    Cancer cells targeting;    USPIO NPs;   

DOI  :  10.1016/j.bmcl.2013.06.037

来源: Elsevier

【 摘 要 】

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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