Synthesis And Characterization of Two Types of Heterogeneous Rings Derived from Sulfamethoxazole and Evaluation Their Bacterial Activity

International Conference on Materials Engineering and Science

Majeed, Haza Sattar^1 ; Fayyadh, Khamaael Mohammed^1

Department of Chemistry, College of Education for Pure Science, University of Tikrit, Iraq^1

关键词: 1H NMR spectroscopy;    Anti-microbial activity;    Glacial acetic acid;    Sulfamethoxazole;    Synthesis and characterizations;    Tetrazole derivatives;    Tetrazoles;    Thiazolidines;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/454/1/012041/pdf
DOI  :  10.1088/1757-899X/454/1/012041

来源: IOP

【 摘 要 】

In this research include preparation three steps of the new derivatives of Sulfamethoxazole drug, the first step involved converting Sulfamethoxazole to Schiff's bases (1), by reaction Sulfamethoxazole with different specific aldehydes in ethanol, presence in glacial acetic acid. While the second step involved reaction Schiff's bases (1) with sodium azide in presence of Benzene (dry) to give new tetrazole derivatives (2). Finally, The third reaction requires synthesis of thiazolidine (3) by reaction of Schiff's bases (1) with 2-mercaptoacetic acid. The prepared compounds were characterized by physical properties, and somewhat of them by IR, 1H-NMR spectroscopy, and study biologic efficacy against two types of bacteria.