The initial pathogenesis of cadmium induced renal toxicity

FEBS Letters

Walker, Lee A.²  Troke, Jeff¹  Griffin, Julian L.¹  Nicholson, Jeremy K.¹  Shore, Richard F.²  Osborn, Dan² 

[1] Biological Chemistry, Biomedical Sciences Division, The Sir Alexander Fleming Building, Exhibition Road, Imperial College of Science, Medicine and Technology, University of London, London SW7 2AZ, UK;NERC Centre for Ecology and Hydrology, Monks Wood, Huntingdon, Cambridgeshire PE28 2LS, UK

关键词: Cadmium toxicity;    1H NMR spectroscopy;    Nephrotoxicity;    Renal tubular acidosis;    Glutamate;    Clethrionomys glareolus;   

DOI  :  10.1016/S0014-5793(00)01843-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The novel application of magic angle spinning ¹H NMR spectroscopy, coupled with pattern recognition techniques, has identified biochemical changes in lipid and glutamate metabolism that precede classical nephrotoxicity. These changes occurred in the bank vole (Clethrionomys glareolus) after chronic dosing, at a low level of exposure and at a renal Cd²⁺ concentration (8.4 μg/g dry wt) that was nearly two orders of magnitude below the WHO critical organ concentration (200 μg/g wet wt). These early stage effects of Cd²⁺ on the biochemistry of renal tissue may reflect adaptation mechanisms to the toxic insult or the preliminary stages of the toxicological cascade.

【 授权许可】

Unknown