Synthetic Studies of Bioactive Substances of 4-Hydroxybenzalhydantoin Derivatives

11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

材料科学;化学;生物科学

Hidayat, I.W.^1 ; Sumiarsa, D.^1 ; Permatasari, M.^1 ; Akania^1 ; Riska^1 ; Priani, L.^1

Department of Chemistry, University of Padjadjaran, Unpad Jatinangor

45363, Indonesia^1

关键词: Acetic anhydrides;    Bioactive substances;    Glacial acetic acid;    Hydantoins;    Sodium acetate;    Standard conditions;    Synthetic study;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/172/1/012024/pdf
DOI  :  10.1088/1757-899X/172/1/012024

来源: IOP

【 摘 要 】

4-hydroxybenzalhydantoin derivatives were synthesized by the condensation reaction between benzaldehydes 12-13 and substituted hydantoins 14-16 under standard conditions of reflux in glacial acetic acid, in the present of sodium acetate and a little amount of acetic anhydride as a catalyst. All compounds were identified by spectral analysis to give 4-hydroxybenzalhydantoins 17-21.