Synthesis, characterization and antimicrobial activities of quaternary chitosan-based materials

Conference of the South African Advanced Materials Initiative 2018

Cele, Zamani^1 ; Ndlandla, Lindokuhle^1 ; Somboro, Anou^2 ; Gyamfi, Daniel^2 ; Balogun, Mohammed^1

Biopolymer Modification and Therapeutics Lab, Polymers and Composites, Materials Science and Manufacturing, Council for Scientific and Industrial Research, Meiring Naude Road, Pretoria, Brummeria

0001, South Africa^1

Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban

4000, South Africa^2

关键词: Anti-microbial activity;    Antibacterial efficacy;    Antimicrobial polymers;    Antimicrobial resistances;    Drug-resistant bacteria;    Gram-positive bacterium;    Hospital acquired infection;    Structure-activity relationships;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/430/1/012048/pdf
DOI  :  10.1088/1757-899X/430/1/012048

来源: IOP

【 摘 要 】

The emergence of new pathogenic strains together with continuous rise of antimicrobial resistance and the death of new antibiotics in the clinical pipeline raise an urgent call for the development of potent antimicrobial agents. There has been growing interest in the use of new agents, such as antimicrobial polymers, as alternatives for therapy and disinfection. Cationic chitosan derivatives, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chlorides (HTCC), have been widely studied as potent antibacterial agents. However, their systemic structure-activity relationship (SAR), activity toward drug resistant bacteria and fungi, and mode of action are very rare. Herein, we investigated antibacterial efficacies of the HTCC polymer derivatives against multidrug resistant bacteria, including clinical isolates. The polymers were found to be active against a variety of bacterial pathogens (MIC = 32-128 μg/mL). Interestingly, these polymeric materials were active against Streptococcus Gram-positive bacteria, which are a predominant cause of hospital-acquired infections (HAIs).