Fabrication and Characterization of Marine Polysaccharides Hemostatic Dressing

4th International Conference on Applied Materials and Manufacturing Technology

材料科学;机械制造

Zhong, Qing-Kun^1,2 ; Hu, Zhang^1 ; Zhang, Dong-Ying^1 ; Li, Si-Dong^1

Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang

524088, China^1

School of Ocean and Meteorology, Guangdong Ocean University, Zhanjiang

524088, China^2

关键词: Carboxymethyl chitosan;    Coagulation performance;    Cross linking agents;    Fabrication and characterizations;    Fabrication process;    Optimum conditions;    Response surface methodology;    Swelling ratio;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/423/1/012172/pdf
DOI  :  10.1088/1757-899X/423/1/012172

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Marine polysaccharides composite hemostatic dressing was fabricated with calcium chloride as the crosslinking agent and carboxymethyl chitosan/sodium alginate as raw materials. On the basis of the pre-experiment, the fabrication process of marine polysaccharides hemostatic dressing was optimized by response surface methodology. The dressing prepared under the optimum conditions was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and then its hemostatic performance was evaluated. The results showed that the optimum conditions for the preparation of hemostatic dressing were as follows: concentration of CMCS is 0.5%, mass ratio of CMCS and SA is 1: 2.5, concentration of CaCl2 is 1.5%. And the swelling ratio of the dressing reached 8020%. FTIR showed that the crosslinking between carboxymethyl chitosan and sodium alginate was successful. Morphology observation found that the appearance was smooth, the pores were large and uniform. Furthermore, the dressing had good coagulation performance.