Optimization of preparation process and characterization of carboxymethyl chitosan/sodium alginate hemostatic sponge

2017 Global Conference on Polymer and Composite Materials

材料科学;化学

Hu, Z.^1 ; Ouyang, Q.Q.^1 ; Cheng, Y.^1 ; Hong, P.Z.^2 ; Liao, M.N.^1 ; Chen, F.J.^3 ; Li, S.D.^1

Faculty of Chemistry and Environment Science, Guangdong Ocean University, Zhanjiang

524088, China^1

College of Food Science and Technology, Guangdong Ocean University, Zhanjiang

524088, China^2

Faculty of Ocean and Meteorology, Guangdong Ocean University, Zhanjiang

524088, China^3

关键词: Carboxymethyl chitosan;    Cross linking agents;    Crosslinking temperatures;    Optimum conditions;    Orthogonal experiment;    Preparation process;    Single-factor experiments;    Vacuum-freeze drying;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/213/1/012045/pdf
DOI  :  10.1088/1757-899X/213/1/012045

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Composite hemostatic sponge was prepared by vacuum freeze-drying using carboxymethyl chitosan and sodium alginate as the main materials and CaCl2as a crosslinking agent. On the basis of single factor experiments, an orthogonal experiment was carried out to optimize the preparation process of hemostatic sponge. The appearance, water absorption, porosity ratio, and in vitro hemostasis of the sponge were evaluated. The optimum conditions to prepare hemostatic sponge were obtained as follows: mass ratio of sodium alginate to carboxymethyl chitosan 4: 1, mass fraction of CaCl22%, and crosslinking temperature 30C. The hemostatic sponge prepared under such conditions was off-white and porous. Its water absorption and porosity ratio were 3050% and 67.23%, respectively. Meanwhile, the hemostatic sponges had significant in vitro procoagulant activity. Therefore, the hemostatic sponge is expected to be developed as a novel medical material.