3D printing biodegradable scaffolds with chitosan materials for tissue engineering

3rd International Youth Scientific Forum with International Participation "New Materials"

Bardakova, K.N.^1,2 ; Demina, T.S.^3 ; Grebenik, E.A.^2 ; Minaev, N.V.^1 ; Akopova, T.A.^3 ; Bagratashvili, V.N.^1 ; Timashev, P.S.^1,2

Institute of Photonic Technologies, Federal Research Centre Crystallography and Photonics, Russian Academy of Sciences, 2 Pionerskaya Str., Troitsk, Moscow

142190, Russia^1

Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya st., Moscow

119991, Russia^2

Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, 70 Profsoyuznaya Str., Moscow

117393, Russia^3

关键词: Biodegradable scaffold;    Chitosan materials;    Chitosan scaffold;    Degenerative disease;    Solvent free reaction;    Spinal cord injuries (SCI);    Three dimensional scaffold;    Two photon polymerization;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/347/1/012009/pdf
DOI  :  10.1088/1757-899X/347/1/012009

来源: IOP

【 摘 要 】

Chitosan-g-oligo (L,L-lactide) copolymer was synthesized through a solvent-free reaction in an extruder. Three-dimensional scaffolds based on photosensitive composition contained the synthetized copolymer were formed by two-photon polymerization. The optimum ratio of components, methods of preparation of photopolymerizable mixtures, parameters of the laser structuring and procedure of washing from unbound crosslinkers have been optimized. Chitosan scaffolds were non-cytotoxic and might therefore be a suitable candidate for treating spinal cord injuries and other neuronal degenerative diseases.