Radially patterned transplantable biodegradable scaffolds as topographically defined contact guidance platforms for accelerating bone regeneration

Journal of Biological Engineering

Sunho Park¹  Yonghyun Gwon¹  Taeseong Han¹  Hyoseong Kim¹  Woochan Kim¹  Jangho Kim¹ 

[1] Department of Rural and Biosystems Engineering, Chonnam National University;

关键词: Critical-sized bone defect;    Bone tissue engineering;    Radially pattern;    Transplantable;    Biodegradable scaffold;   

DOI  :  10.1186/s13036-021-00263-8

来源: DOAJ

【 摘 要 】

Abstract Background The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however, it has critical limitations. Bone tissue engineering has been proposed as a viable alternative, not only for replacing the current standard treatment, but also for producing complete regeneration of bone tissue without complex surgical treatments or tissue transplantation. In this study, we proposed a transplantable radially patterned scaffold for bone regeneration that was defined by capillary force lithography technology using biodegradable polycaprolactone polymer. Results The radially patterned transplantable biodegradable scaffolds had a radial structure aligned in a central direction. The radially aligned pattern significantly promoted the recruitment of host cells and migration of osteoblasts into the defect site. Furthermore, the transplantable scaffolds promoted regeneration of critical-sized bone defects by inducing cell migration and differentiation. Conclusions Our findings demonstrated that topographically defined radially patterned transplantable biodegradable scaffolds may have great potential for clinical application of bone tissue regeneration.

【 授权许可】

Unknown