Targeting IL-17 AND IL-17D receptors of rheumatoid arthritis using phytocompounds: A Molecular Docking study

14th International Conference on Science, Engineering and Technology

自然科学;工业技术

Thabitha, A.^1 ; Mohamed Thoufic Ali, A.M.^2 ; Kumari, Singh Shweta^1 ; Rakhi^1 ; Swami, Varsha^1 ; Mohana Priya, A.^1 ; Sajitha Lulu, S.^1

Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu

632014, India^1

Department of Integrative Biology, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu

632014, India^2

关键词: Anti-inflammatories;    Anti-inflammatory mechanism;    Autoimmune conditions;    Fibroblast growth factor;    Inflammatory immune response;    Negative regulators;    Rheumatoid arthritis;    Therapeutic strategy;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022040/pdf
DOI  :  10.1088/1757-899X/263/2/022040

来源: IOP

【 摘 要 】

Rheumatoid arthritis (RA) is a chronic autoimmune condition of the connective tissue in synovial joints, characterized by inflammation which can lead to bone and cartilage destruction. IL-17 and IL-17D cytokines produced by a number of cell types, primarily promote pro-inflammatory immune responses and negative regulator in fibroblast growth factor signalling. Thus, the promising therapeutic strategies focus on targeting these cytokines, which has led to the identification of effective inhibitors. However, several studies focused on identifying the anti-arthritic potential of natural compounds. Therefore, in the present study we undertook in silico investigations to decipher the anti-inflammatory prospective of phytocompounds by targeting IL-17 and IL-17D cytokines using Patch Dock algorithm. Additionally, IL-17 and IL-17D proteins structure were modelled and validated for molecular docking study. Further, phytocompounds based on anti-inflammatory property were subjected to Lipinski filter and ADMET properties indicated that all of these compounds showed desirable drug-like criteria. The outcome of this investigation sheds light on the anti-inflammatory mechanism of phytocompounds by targeting IL-17 and IL-D for effective treatment of RA.