Membrane stabilization activity as anti-inflammatory mechanisms of Vernonia amygdalina leaves extracts

1st International Conference on Tropical Studies and Its Application

Nuryanto, M.K.^1 ; Paramita, S.^1 ; Iskandar, A.^2

Laboratory of Community Medicine, Faculty of Medicine, Mulawarman University, Jl. Kerayan Kampus Gunung Kelua, East Kalimantan, Samarinda

75119, Indonesia^1

Laboratory of Microbiology, Faculty of Medicine, Mulawarman University, Jl. Kerayan Kampus Gunung Kelua, East Kalimantan, Samarinda

75119, Indonesia^2

关键词: Anti-inflammatories;    Anti-inflammatory activity;    Anti-inflammatory agents;    Anti-inflammatory mechanism;    Chronic inflammation;    Experimental methods;    Membrane stabilization;    Muscle stiffness;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/144/1/012023/pdf
DOI  :  10.1088/1755-1315/144/1/012023

来源: IOP

【 摘 要 】

Inflammation is a normal process in the human body as a response to injury from healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Anti-inflammatory agents generally used for those conditions, have several side effects to patients. The aim of this research was to find alternative anti-inflammatory agents, especially from natural sources. Vernonia amygdalina knew locally as "daun afrika" belong to family Apiaceae is one of those potential natural sources for alternative anti-inflammatory agents. This plant is known astraditionalmedicine from East Kalimantanfor health problems caused by the muscle stiffness and used as material in this research. The experimental method of anti-inflammatory measurement using membrane stabilization activity for V. amygdalina leaves extracts. The results showed that significant differences of EC50(p50of V.amygdalina leaves extracts showed the potential anti-inflammatory activities. It could be concluded that V. amygdalina leaves extracts to have anti-inflammatory activities, which could be further developed as a new natural source of the anti-inflammatory agents.